Jan 1, 1980

A new approach to detection of antigen-antibody complexes by microcalorimetric measurements of heat production in blood cells

Journal of Immunological Methods
M MontiI Wadsö

Abstract

Using batch microcalorimeters of the thermopile conduction type, heat production was measured in human blood in the presence of defined antigens and their specific antibodies. A large increase in heat production, reflecting increased metabolic activity in the blood cells, was found when antigens and specific antisera at certain antigen-antibody proportions were mixed with the blood. The reproducibility and specificity of the method were found to be very good. The present results indicate that calorimetry may be a useful technique for detection of antigen-antibody complexes.

Mentioned in this Paper

Calorimetry
Immune complex
Ovalbumin
Plasma Albumin
Blood Cells

About this Paper

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