PMID: 8950645Nov 1, 1996Paper

A new approach to mechanical testing and modeling of biological tissues, with application to blood vessels

Journal of Biomechanical Engineering
L J Brossollet, R P Vito

Abstract

The collection and processing of data from mechanical tests of biological tissues usually follow classical principles appropriate for studying engineering materials. However, difficulties specific to biological tissues have generally kept such methods from producing quantitative results for statistically-oriented studies. This paper demonstrates a different approach linking testing and data reduction with modern statistical tools. Experimental design theory is used to minimize the detrimental effects of collinearity on the stability of the parameters in constitutive equations. The numerical effects of time-dependent biasing factors such as viscoelasticity are reduced by randomizing the order of collection of data points. Some of the parameters of the model are allowed to vary from specimen to specimen while the others are computed once from a database of designed experiments on several specimens. Finally, a new self-modeling algorithm based on principal component analysis is used to generate uncorrelated parameters for a model that is linear in its specimen-dependent parameters. The method, associated with a recently published complementary energy formulation for vascular mechanics, is illustrated with biaxial canine saphenous ...Continue Reading

References

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Feb 1, 1990·The American Journal of Physiology·A M MuijtjensT Arts
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Jan 1, 1993·Annals of Biomedical Engineering·J D HumphreyM Anjanappa
Feb 1, 1997·Journal of Biomechanical Engineering·L J Brossollet, R P Vito

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Citations

Nov 8, 2006·Annals of Biomedical Engineering·Hyunggun KimJia Lu
Feb 1, 1997·Journal of Biomechanical Engineering·L J Brossollet, R P Vito
Oct 26, 1999·Journal of Biomechanical Engineering·M S Sacks
Feb 7, 2007·Expert Review of Medical Devices·Michael S SacksPaul Schmidt
May 6, 2003·Annual Review of Biomedical Engineering·Michael S Sacks, Wei Sun
May 6, 2003·Annual Review of Biomedical Engineering·Raymond P Vito, Stacey A Dixon
Mar 1, 2006·Journal of Biomechanical Engineering·Jean-Luc Dulong, Cécile Legallais
May 20, 2003·Journal of Biomechanical Engineering·Stacey A DixonRaymond P Vito
Aug 22, 2003·Journal of Biomechanical Engineering·Wei SunMichael J Scott
Sep 26, 2006·Journal of Biomechanical Engineering·Hyunggun KimKrishnan B Chandran
Jan 23, 2015·BMC Health Services Research·Pim P ValentijnMarc A Bruijnzeels
Dec 9, 2016·Journal of the Royal Society, Interface·Bruno V RegoMichael S Sacks

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