A new approach to ovarian reserve testing.

Fertility and Sterility
Wenjie SunJames H Segars

Abstract

To critically examine ovarian reserve testing before assisted reproduction. A PUBMED computer search to identify relevant literature. Multiple sites. Patients undergoing assisted reproduction. Testing for ovarian reserve. Assisted reproductive technology (ART) and pregnancy outcomes. The prevalence of ovarian insufficiency varies significantly for women aged 30-45 years. Generalization or averaging of threshold values across different aged women leads to very poor sensitivity, specificity, and positive predictive value for all tests of ovarian reserve. Because of the changing prevalence of ovarian insufficiency, there is no single, suitable threshold value for any screening test of ovarian reserve. Our analysis supports dividing impaired ovarian reserve into two groups: age-dependent ovarian aging (physiologic) and premature (nonphysiologic) reductions in the oocyte pool. Interpretation of any screening test used requires that age is considered as a variable. To guide clinical interpretation of test results, we suggest using a nomogram of FSH values versus expected delivery rate-per-cycle-start with ART for a given age. Proper interpretation of screening tests for ovarian insufficiency in couples considering ART is important as...Continue Reading

References

Aug 6, 1998·British Journal of Obstetrics and Gynaecology·S LaveryR Winston
Mar 25, 2000·American Journal of Human Genetics·S B FreemanS L Sherman
Jan 11, 2000·Clinical Obstetrics and Gynecology·B J Van Voorhis, C H Syrop
Oct 10, 2001·Fertility and Sterility·A J LeviR T Scott
Oct 27, 2001·Seminars in Reproductive Medicine·J Collins
Jul 9, 2002·Human Reproduction Update·Egbert R te Velde, Peter L Pearson
Oct 9, 2002·Acta Obstetricia Et Gynecologica Scandinavica·György CsemiczkyGabriel Fried
Nov 29, 2002·Human Reproduction·I A J van RooijA P N Themmen
Jul 29, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Koray ElterTanju Pekin
Sep 20, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·S MuttukrishnaP Serhal
Sep 30, 2005·Cytogenetic and Genome Research·D Warburton
Aug 8, 2006·Human Reproduction Update·F J BroekmansC B Lambalk

❮ Previous
Next ❯

Citations

Jul 19, 2011·Journal of Assisted Reproduction and Genetics·Fang-Ting KuoMargareta D Pisarska
Dec 21, 2011·Journal of Assisted Reproduction and Genetics·Berna SeckinGulnur Ozaksit
May 3, 2011·Human Reproduction·Andrea WeghoferNorbert Gleicher
Apr 23, 2011·Obstetrical & Gynecological Survey·Mary Ellen PavoneRalph R Kazer
Jun 26, 2010·Reproductive Biology and Endocrinology : RB&E·Norbert GleicherDavid H Barad
May 21, 2014·Journal of Assisted Reproduction and Genetics·Alexis D GreeneJames H Segars
Oct 6, 2009·Human Fertility : Journal of the British Fertility Society·Ahmed GibreelNeil P Johnson
Jan 29, 2011·Reproductive Biomedicine Online·David H BaradNorbert Gleicher
Nov 4, 2010·Reproductive Biomedicine Online·Jeff G WangMark V Sauer
Feb 18, 2010·Reproductive Biomedicine Online·Murid JavedRobert F Casper
Jun 1, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Anna Garcia-Alix GrynnerupSteen Sørensen
Feb 14, 2015·Journal of Minimally Invasive Gynecology·Giulia AlabisoErrico Zupi
Jan 26, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Luigi DevotoPaulina Kohen
May 9, 2013·Systems Biology in Reproductive Medicine·Amir WeissAndrew P Levy
Jul 11, 2009·Endocrine Reviews·F J BroekmansB C Fauser
Oct 6, 2016·The Journal of Clinical Endocrinology and Metabolism·Ophelia YinJames H Segars
Oct 28, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.