A new approach to predict lymph node metastasis in solid lung adenocarcinoma: a radiomics nomogram

Journal of Thoracic Disease
Xinguan YangYubao Guan

Abstract

Lymph node metastasis (LNM) of lung cancer is an important factor related to survival and recurrence. The association between radiomics features of lung cancer and LNM remains unclear. We developed and validated a radiomics nomogram to predict LNM in solid lung adenocarcinoma. A total of 159 eligible patients with solid lung adenocarcinoma were divided into training (n=106) and validation cohorts (n=53). Radiomics features were extracted from venous-phase CT images. We built a radiomics nomogram using a multivariate logistic regression model combined with CT-reported lymph node (LN) status. The performance of the radiomics nomogram was evaluated using the area under curve (AUC) of receiver operating characteristic curve. We performed decision curve analysis (DCA) within training and validation cohorts to assess the clinical usefulness of the nomogram. Fourteen radiomics features were chosen from 94 candidate features to build a radiomics signature that significantly correlated with LNM. The model showed good calibration and discrimination in the training cohort, with an AUC of 0.871 (95% CI: 0.804-0.937), sensitivity of 85.71% and specificity of 77.19%. In the validation cohort, AUC was 0.856 (95% CI: 0.745-0.966), sensitivity ...Continue Reading

Citations

Apr 2, 2019·AJR. American Journal of Roentgenology·Aiping ChenBinsheng Zhao
Sep 19, 2019·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Marta BogowiczStephanie Tanadini-Lang
Jan 31, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Geewon LeeHo Yun Lee
May 16, 2020·Frontiers in Oncology·Mengmeng Yan, Weidong Wang
Jun 20, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Martina SolliniMargarita Kirienko
Jul 14, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·José Sanz-Santos, Sergi Call
Sep 25, 2018·Journal of Radiation Research·Hidetaka ArimuraMasahiro Yamada
Jul 23, 2020·Methods : a Companion to Methods in Enzymology·Laurent DercleCharlotte Robert
Dec 4, 2020·World Journal of Clinical Cases·E-Nuo CuiXi-Ran Jiang
Jun 21, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Isabella Fornacon-WoodGareth J Price

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