A new approach to reduce uncertainties in space radiation cancer risk predictions

PloS One
Francis A Cucinotta

Abstract

The prediction of space radiation induced cancer risk carries large uncertainties with two of the largest uncertainties being radiation quality and dose-rate effects. In risk models the ratio of the quality factor (QF) to the dose and dose-rate reduction effectiveness factor (DDREF) parameter is used to scale organ doses for cosmic ray proton and high charge and energy (HZE) particles to a hazard rate for γ-rays derived from human epidemiology data. In previous work, particle track structure concepts were used to formulate a space radiation QF function that is dependent on particle charge number Z, and kinetic energy per atomic mass unit, E. QF uncertainties where represented by subjective probability distribution functions (PDF) for the three QF parameters that described its maximum value and shape parameters for Z and E dependences. Here I report on an analysis of a maximum QF parameter and its uncertainty using mouse tumor induction data. Because experimental data for risks at low doses of γ-rays are highly uncertain which impacts estimates of maximum values of relative biological effectiveness (RBEmax), I developed an alternate QF model, denoted QFγAcute where QFs are defined relative to higher acute γ-ray doses (0.5 to 3 G...Continue Reading

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Citations

Jul 17, 2015·Life Sciences in Space Research·Francis A CucinottaMyung-Hee Y Kim
Aug 11, 2015·Life Sciences in Space Research·Mary Helen Barcellos-HoffMichael M Weil
Apr 20, 2016·Radiation Research·Polly Y ChangEleanor A Blakely
Mar 24, 2018·International Journal of Radiation Biology·Scott Bright, Munira Kadhim
Apr 17, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·G N Timoshenko, M I Belvedersky
Dec 24, 2018·Radiation Protection Dosimetry·Francis A CucinottaPremkumar B Saganti
Jan 23, 2019·International Journal of Radiation Biology·Dudley T Goodhead
Sep 29, 2019·International Journal of Molecular Sciences·Hiroko IkedaAkihisa Takahashi
Oct 31, 2019·International Journal of Molecular Sciences·Shankari NairCharlot Vandevoorde
Jul 1, 2018·International Journal of Particle Therapy·Akihisa TakahashiYukari Yoshida
Nov 6, 2015·Frontiers in Oncology·Kerry A GeorgeFrancis A Cucinotta
Dec 16, 2020·International Journal of Molecular Sciences·Binod PrasadMarcus Krüger
Jun 28, 2016·Life Sciences in Space Research·Deepa M SridharanJanice M Pluth
May 31, 2017·Life Sciences in Space Research·Shubhankar SumanKamal Datta
Jul 5, 2019·International Journal of Radiation Oncology, Biology, Physics·Shubhankar SumanKamal Datta
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Methods Mentioned

BETA
γ-ray
chromosomal aberrations

Software Mentioned

Sigmaplot
DEVCAN

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