PMID: 11903149Mar 21, 2002Paper

A new approach to the study of latissimus dorsi muscle vasoreactivity in rats

Artificial Organs
K De AngelisM C Irigoyen

Abstract

In this paper we describe a new approach to the study of changes in latissimus dorsi (LD) muscle microcirculation in rats. The experiments were carried out under anesthesia in normal male Wistar rats (C, n = 6) and in diabetes-induced rats (D, streptozotocin, 50 mg/kg, i.v., n = 6). The left LD muscle was exposed in order to preserve the proximal tendon with its thoracodorsal nerve and artery. The animal was kept in lateral decubitus over a heating board attached to the mechanical stage of the intravital microscope. The ventral surface of the muscle was exposed over a transparent plate and fixing. The image of the LD vascularization was transferred to the camera system, which was connected to a microcomputer equipped with software (KS-300, Kontron Elektronik, Munich, Germany) for image storage. The vasoreactivity of LD was analyzed by changes in arteriole diameter after topically administered noradrenaline (0.3 microg/ml) and acetylcholine (300 microg/ml). The microscopic image provided by the described optical setup permitted clear resolution of capillary vessels and a stable preparation over a period of 3-4 h. D rats showed increased vasodilatation (29 +/- 2% vs. 18 +/- 2.6% in C) and similar vasoconstriction (25.5 +/- 3% vs....Continue Reading

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Citations

Jun 19, 2013·Surgical Neurology International·Jose Carlos LynchMariangela Barbi Gonçalves

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