A new approach towards biomarker selection in estimation of human exposure to chiral chemicals: a case study of mephedrone

Scientific Reports
Erika CastrignanòBarbara Kasprzyk-Hordern

Abstract

Wastewater-based epidemiology is an innovative approach to estimate public health status using biomarker analysis in wastewater. A new compound detected in wastewater can be a potential biomarker of an emerging trend in public health. However, it is currently difficult to select new biomarkers mainly due to limited human metabolism data. This manuscript presents a new framework, which enables the identification and selection of new biomarkers of human exposure to drugs with scarce or unknown human metabolism data. Mephedrone was targeted to elucidate the assessment of biomarkers for emerging drugs of abuse using a four-step analytical procedure. This framework consists of: (i) identification of possible metabolic biomarkers present in wastewater using an in-vivo study; (ii) verification of chiral signature of the target compound; (iii) confirmation of human metabolic residues in in-vivo/vitro studies and (iv) verification of stability of biomarkers in wastewater. Mephedrone was selected as a suitable biomarker due to its high stability profile in wastewater. Its enantiomeric profiling was studied for the first time in biological and environmental matrices, showing stereoselective metabolism of mephedrone in humans. Further biom...Continue Reading

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Citations

Nov 21, 2019·Critical Reviews in Toxicology·João L GonçalvesJosé S Câmara
Jun 3, 2021·International Journal of Environmental Research and Public Health·Tomáš MackuľakAndrea Butor Škulcová
Jun 22, 2021·Forensic Science International : Synergy·Ivan LangaCláudia Ribeiro

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Methods Mentioned

BETA
circular dichroism

Software Mentioned

Xcalibur
- BBD Pathway Prediction System
Bruker Compass DataAnalysis
TargetLynx
MetID
Percepta
IntelliTarget
Metabolite Identification ( MetID )
ACD
Labs

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