A new austenitic stainless steel with a negligible amount of nickel: an in vitro study in view of its clinical application in osteoporotic bone

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Milena FiniA Cigada

Abstract

A biomaterial named P558 is a new austenitic stainless steel (SS) with a negligible amount of Ni (<0.20%). In previous in vitro and in vivo studies it was compared with conventional SS and Ti6Al4V and shown to be a promising material in orthopedics. Because osteoporosis is a type of pathology very often encountered in implanted patients and can be studied with in vitro models, the purpose of the present study was to evaluate P558 in vitro through comparison of normal (nOB) with osteopenic (oOB) bone-derived primary rat osteoblasts. Osteoblasts were cultured directly on P558 and polystyrene as controls for 72 h. Osteoblast proliferation, adhesion, and activity (ALP, OC, TGF-beta1, and IL-6) were evaluated at 24 and 72 h. Results demonstrated that the growth of nOB and oOB cultured on P558 was not affected negatively when compared to control. Cells on P558 did not show any alteration in terms of adhesion, proliferation, and metabolic marker production in nOB and oOB cultures, and a significant increase in ALP, OC, and TGF-beta1 production was observed. SEM images revealed no alteration in cell morphology. The current findings demonstrate that P558 promotes osteoblast proliferation, activation, and differentiation not only in norm...Continue Reading

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Citations

Sep 8, 2011·Journal of Bone and Mineral Metabolism·Milena FiniMatilde Tschon
Dec 20, 2005·Journal of Materials Science. Materials in Medicine·Carmen GiordanoRoberto Giardino
Oct 30, 2009·Journal of Materials Science. Materials in Medicine·Saeed HesarakiDavood Sharifi
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Nov 8, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Simona RadiceMarkus A Wimmer
Oct 8, 2021·Advanced Materials·Ady SuwardiXian Jun Loh

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