A new benzophenanthridine alkaloid and other bioactive constituents from the stem bark of Zanthoxylum heitzii

Fitoterapia
Helle WangensteenKarl Egil Malterud

Abstract

Heitziquinone (7), a new benzophenanthridine alkaloid, together with five known compounds; isoarnottianamide (5), rhoifoline B (6), isobauerenol (8), 6-hydroxypellitorine (9) and sylvamide (10), were isolated as minor compounds from the hexane extract of stem bark from Zanthoxylum heitzii. Four previously reported compounds (1-4) were found, as well. Compounds 5 and 7 were both found to exist as 4:1 mixtures of two atropisomers. The structures were elucidated by 1D and 2D NMR spectroscopy and by mass spectrometry. Compounds 5-10 were identified for the first time in this species, and they are all rare natural compounds. Pellitorine (4), one of the main compounds from the hexane bark extract, was found to be responsible for the brine shrimp larvae toxicity (LC50 37μM, 8μg/ml) of the crude extract (LC50 24μg/ml). Low cytotoxicity against a macrophage cell line was observed.

References

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Citations

Sep 22, 2016·Malaria Journal·Christopher Dean GoodmanHelle Wangensteen
Jul 31, 2020·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Aug 31, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Jacques Joël EssogoConstant Anatole Pieme
Sep 14, 2017·BMC Complementary and Alternative Medicine·Yongqiang TianMingquan Guo

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