A New Bioactive Metabolite Isolated from the Red Sea Marine Sponge Hyrtios erectus

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Sameh S ElhadySafwat A Ahmed

Abstract

Chemical investigation of the lipophilic fraction of Hyrtios erectus, a Red Sea sponge, yielded a new pentacyclic nitrogen-containing scalarane; 24-methoxypetrosaspongia C (1), together with the previously reported scalaranes sesterstatin 3 (2), 12-deacetyl-12-epi-scalaradial (3) and 12-deacetyl-12,18-di-epi-scalaradial (4). The compounds were identified using HRESIMS, 1D and 2D NMR experiments. The isolated compounds showed growth inhibitory activity against hepatocellular carcinoma (HepG2), colorectal carcinoma (HCT-116) and breast adenocarcinoma cells (MCF-7).

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Citations

Jun 29, 2016·Biomolecules & Therapeutics·Komal AnjumSyed Shams Ul Hassan
Apr 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdulrahman M AlahdalSameh S Elhady
May 18, 2020·Marine Drugs·Oh-Seok KwonJongheon Shin
Mar 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yeon-Ju LeeJihoon Lee
Feb 26, 2020·Metabolites·Samah O AlshehriReda F A Abdelhameed
Jan 18, 2018·Natural Product Reports·John W BluntMichèle R Prinsep
Dec 23, 2020·Natural Product Reports·Keke Li, Kirk R Gustafson
Jan 4, 2021·Journal of Cancer Research and Clinical Oncology·Jiaen WeiZunnan Huang
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Taitusi TaufaRobert A Keyzers

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Datasets Mentioned

BETA
SAA-59

Methods Mentioned

BETA
NMR
column chromatography

Software Mentioned

NEOSY

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