A new biocompatible material (Lyoplant) for the therapy of congenital abdominal wall defects: first experimental results in rats

Pediatric Surgery International
Thomas MeyerBurkhard Höcht

Abstract

Congenital abdominal wall defects are impressive and dramatic malformations. Common surgical therapy for omphalocele and gastroschisis is to place the herniated viscera back into the abdomen and to close the fascia. Small defects can be closed directly by surgical treatment. In large defects, resorbable and non-resorbable artificial materials are necessary to close the fascia. The aim of this study is to find out whether new biocompatible materials might be suitable for the treatment of such abdominal wall defects. A median laparotomy was performed in young Wistar rats with a body weight of 75-100 g. Then a full thickness defect was created by excising a 1.5 x 2.5 cm segment including fascia, muscles and peritoneum. These defects were then closed by implantation of a PTFE mesh (Dual-Mesh, n = 6), a PPP mesh (Prolene, n = 6) or a new biocompatible mesh (NBM; Lyoplant, n = 6). Each rat was examined daily after treatment. Bodyweight was determined and the possible development of a hernia was monitored. After 6 weeks, the abdomen was opened again. Adhesions to the intestine were measured and the abdominal wall was removed for histological and tensiometric examination. (1) Compared to the untreated controls, all animals showed physi...Continue Reading

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Citations

Sep 17, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·T MeyerC-T Germer
Jan 10, 2013·Trends in Biotechnology·Kim E M BendersJos Malda
Aug 19, 2015·Acta Biomaterialia·Perla AyalaElliot L Chaikof
Aug 26, 2009·Acta Cirúrgica Brasileira·Walter da SilvaMurched Omar Taha
May 25, 2016·Archives of Plastic Surgery·Sara FuentesAndres Gomez
Jan 15, 2015·European Child & Adolescent Psychiatry·Ann Kristin KnudsenLeila Torgersen
Jul 23, 2014·Biomedical Materials·L MancusoG Cao
Dec 12, 2019·Tissue Engineering and Regenerative Medicine·F WindeTh Meyer

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