A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat

Current Eye Research
Zahidul KarimTakazumi Taniguchi

Abstract

We investigated whether lomerizine, a new diphenylmethylpiperazine calcium channel blocker, exerted a neuroprotective effect on axonal or retinal damage induced by optic nerve injury in the rat. A partial crush lesion was inflicted unilaterally on the optic nerve, 2 mm behind the globe, in adult Wistar albino rats. Animals were treated with the vehicle, 10 or 30 mg/kg lomerizine. Each solution was given orally twice daily for 4 weeks. One week before euthanization, Fluoro-Gold (FG) was injected into both superior colliculi to retrogradely label surviving retinal ganglion cells (RGCs). Approximately 1 month after the optic nerve injury, the retinal damage was assessed morphologically, and the optic nerve axons surrounding the initial lesion were examined histologically. The mean RGC density in the control group decreased to 65.9 +/- 1.32% of the contralateral eye, whereas the systemic application of 10 or 30 mg/kg of lomerizine significantly enhanced the RGC survival to 88.1 +/- 0.38% and 89.8 +/- 0.28%, respectively. Histological examination of damaged axons revealed no significant enhancement of the density or total number of axons of the retinal ganglion cells in the lomerizine-treated group. The crush force we employed cause...Continue Reading

References

Jul 1, 1992·Journal of Neurobiology·L McKerracher, A Hirscheimer
Jun 1, 1992·Archives of Ophthalmology·K TakahashiM O Tso
Mar 27, 1989·Brain Research·W C TaftR J DeLorenzo
Mar 1, 1985·Journal of Neurophysiology·S A Bloomfield, J E Dowling
Mar 1, 1985·Journal of Neurophysiology·S A Bloomfield, J E Dowling
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S T BradyW O McClure
Apr 1, 1981·Archives of Ophthalmology·H A QuigleyA E Maumenee
May 1, 1983·Annals of Internal Medicine·J N Cohn
Jun 1, 1995·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M WeberJ A Sahel
May 1, 1993·Journal of the Neurological Sciences·G W Eschweiler, M Bähr
Mar 1, 1996·Archives of Ophthalmology·E B DreyerS A Lipton
Jul 17, 1998·Vision Research·S M Wu, B R Maple
Nov 5, 1998·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·K AdachiY Honda
Jul 1, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G MoalemM Schwartz
Jul 23, 1999·Survey of Ophthalmology·N N OsborneM S Nash
Nov 5, 1999·Experimental Eye Research·A Sawada, A H Neufeld
Apr 28, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·N ToriuH Hara
Dec 31, 2002·Experimental Neurology·María P Lafuente López-HerreraManuel Vidal-Sanz
Jul 29, 2003·Investigative Ophthalmology & Visual Science·Hana Levkovitch-VerbinDanielle F Valenta
Feb 27, 2004·Investigative Ophthalmology & Visual Science·Kazumi MaedaTetsuya Yamamoto
Mar 24, 2004·Brain Research Bulletin·Michal Schwartz
Aug 1, 1993·Current Biology : CB·B A BarresM C Raff

❮ Previous
Next ❯

Citations

Jan 3, 2009·Experimental Neurology·Melinda FitzgeraldSarah A Dunlop
Oct 4, 2008·The Journal of International Medical Research·N WuY Wang
Nov 6, 2018·International Journal of Molecular Sciences·Yilin MaoMelinda Fitzgerald

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.