A New Chapter in Genetic Medicine: RNA Editing and its Role in Disease Pathogenesis

Trends in Molecular Medicine
Khatuna GagnidzeF Nina Papavasiliou

Abstract

The transfer of genomic information from DNA to mRNA to protein usually occurs with high fidelity, but can also be subverted by a programmed RNA sequence alteration termed 'RNA editing', involving deamination of adenosine to inosine (decoded as guanosine), or of cytosine to uracil. These sequence changes can lead to cellular heterogeneity by generating variable sets of transcripts within otherwise identical cells. Recent studies have demonstrated that editing is most prevalent in cells and tissues with high propensity for plasticity. Within those, RNA editing reproducibly targets transcripts of related function, altering the outcomes of entire pathways at once. In ongoing work, changes in patterns of editing have been correlated with neuronal disease pathogenesis, suggesting that RNA editing harbors diagnostic potential.

Citations

Jan 30, 2019·Nature Biotechnology·Tobias MerkleThorsten Stafforst
Oct 26, 2018·Circulation. Genomic and Precision Medicine·Aikaterini Gatsiou, Konstantinos Stellos
Feb 17, 2019·Translational Psychiatry·Fabrice ChimientiDinah Weissmann
Aug 14, 2020·International Journal of Molecular Sciences·Iwona Rzeszutek, Aditi Singh
Mar 2, 2019·Nucleic Acids Research·Jun DingZiv Bar-Joseph
Jan 9, 2021·International Journal of Genomics·Javad BehrooziHabibollah Mahmoodzadeh
Apr 16, 2020·Trends in Genetics : TIG·Youqiong YeLeng Han
Jul 2, 2021·Nucleic Acids Research·Anna S StroppelThorsten Stafforst
Sep 10, 2021·Molecular and Cellular Biochemistry·Pavan Kumar Mysuru ShivalingappaSharmila A Bapat

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