A new classification for meibomian gland diseases with in vivo confocal microscopy

Journal français d'ophtalmologie
Matthieu RandonAntoine Labbé

Abstract

Meibomian gland dysfunction (MGD) is a frequent disorder often associated with dry eye disease. Slit-lamp examination with digital expression of the tarsal Meibomian glands allows examination of the contents of the distal Meibomian gland and the meatus. However, the Meibomian epithelium, interglandular space and proximal secretions cannot be clinically assessed. In vivo confocal microscopy (IVCM) is a rapid and non-invasive imaging technique that provides high-resolution images of the ocular surface and eyelids. The primary objective of the present study was to establish a classification of MGD with IVCM. Secondary objectives were to evaluate this scoring system by analyzing the correlation with OSDI, infrared (IR) meibography and Demodex infestation. Forty-six dry eye patients (Ocular Surface Disease Index [OSDI] >13) associated with MGD were enrolled. Ten healthy subjects without dry eye disease or blepharitis were also included as controls. An OSDI questionnaire, clinical examination, IVCM and infrared meibography of the lower lid were performed in all subjects by the same examiner. A new MGD score was established based on IVCM findings: the first stage was Meibomian obstruction with a clear epithelium, the second stage was ...Continue Reading

References

Jul 1, 1991·Cornea·W D MathersJ V Jester
May 18, 2000·Archives of Ophthalmology·R M SchiffmanB L Reis
Dec 18, 2002·Cornea·Hiroto Obata
Feb 14, 2009·The Ocular Surface·Antoine LabbéChristophe Baudouin
Sep 23, 2009·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Nathan EfronNicola Pritchard
Sep 18, 2010·Investigative Ophthalmology & Visual Science·Takashi KojimaKazuo Tsubota
Mar 20, 2012·Investigative Ophthalmology & Visual Science·Eloy VisoFrancisco Gude
Dec 28, 2012·The British Journal of Ophthalmology·Luca AgnifiliLeonardo Mastropasqua
Jan 17, 2013·The Ocular Surface·Yumiko BanJun Shimazaki
May 28, 2013·Journal français d'ophtalmologie·M Labetoulle, C Baudouin
Nov 13, 2013·Current Eye Research·Edoardo VillaniMurat Dogru
Mar 15, 2014·The British Journal of Ophthalmology·Christophe BaudouinUNKNOWN ODISSEY European Consensus Group members
Apr 15, 2014·The Ocular Surface·Anthony J BronMichael A Lemp
Sep 26, 2014·The British Journal of Ophthalmology·Matthieu RandonChristophe Baudouin

❮ Previous
Next ❯

Citations

Dec 14, 2019·Eye & Contact Lens·William W BinottiPedram Hamrah
Oct 6, 2019·The British Journal of Ophthalmology·Lixing W RenekerAndrew J W Huang
May 26, 2016·The British Journal of Ophthalmology·Hong LiangChristophe Baudouin
Nov 19, 2019·Translational Vision Science & Technology·Mathieu RobinAntoine Labbé
Nov 25, 2020·Indian Journal of Ophthalmology·Krishna Poojita VunnavaKamal B Kapur
Nov 3, 2020·Therapeutic Advances in Ophthalmology·Mashael Al-Namaeh
Jan 14, 2020·Journal français d'ophtalmologie·M RobinA Labbé

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Klinische Monatsblätter für Augenheilkunde
E M MessmerA Kampik
Ocular Immunology and Inflammation
Fatih OzcuraMehmet Rami Helvaci
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Young Shin KimSun Young Jang
© 2022 Meta ULC. All rights reserved