A NEW CLINICAL PREDICTION CRITERION ACCURATELY DETERMINES A SUBSET OF PATIENTS WITH BILATERAL PRIMARY ALDOSTERONISM BEFORE ADRENAL VENOUS SAMPLING.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Tomaz KocjanMojca Jensterle

Abstract

Adrenal venous sampling (AVS) is the only available method to distinguish bilateral from unilateral primary aldosteronism (PA). AVS has several drawbacks, so it is reasonable to avoid this procedure when the results would not affect clinical management. Our objective was to identify a clinical criterion that can reliably predict nonlateralized AVS as a surrogate for bilateral PA that is not treated surgically. A retrospective diagnostic cross-sectional study conducted at Slovenian national endocrine referral center included 69 consecutive patients (mean age 56 ± 8 years, 21 females) with PA who underwent AVS. PA was confirmed with the saline infusion test (SIT). AVS was performed sequentially during continuous adrenocorticotrophic hormone (ACTH) infusion. The main outcome measures were variables associated with nonlateralized AVS to derive a clinical prediction rule. Sixty-seven (97%) patients had a successful AVS and were included in the statistical analysis. A total of 39 (58%) patients had nonlateralized AVS. The combined criterion of serum potassium ≥3.5 mmol/L, post-SIT aldosterone <18 ng/dL, and either no or bilateral tumor found on computed tomography (CT) imaging had perfect estimated specificity (and thus 100% positive...Continue Reading

References

Sep 1, 1984·Hypertension·O B HollandC E Gomez-Sanchez
Jan 20, 2005·Surgery·William F YoungJon A van Heerden
May 4, 2006·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroMauro Maccario
Dec 13, 2006·Journal of the American College of Cardiology·Gian Paolo RossiUNKNOWN PAPY Study Investigators
Jan 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroFranco Veglio
Jun 17, 2008·The Journal of Clinical Endocrinology and Metabolism·John W FunderUNKNOWN Endocrine Society
Jan 9, 2009·Clinical Endocrinology·William F Young, Anthony W Stanson
Sep 2, 2009·Annals of Internal Medicine·William F Young
Jan 19, 2012·European Journal of Endocrinology·Miroslav SolarJiri Ceral
Mar 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Gian Paolo RossiAchille Cesare Pessina
Aug 25, 2012·The Journal of Clinical Endocrinology and Metabolism·Elselien M KüpersOlivier Steichen
Mar 8, 2014·The Journal of Clinical Endocrinology and Metabolism·Anna RiesterMarcus Quinkler
Apr 4, 2014·Journal of Human Hypertension·K NanbaM Naruse
May 7, 2014·The Journal of Clinical Endocrinology and Metabolism·Vivien LimWilliam F Young
May 17, 2014·The Lancet. Diabetes & Endocrinology·Silvia MonticonePaolo Mulatero
Aug 15, 2014·The Journal of Clinical Endocrinology and Metabolism·Silvia MonticonePaolo Mulatero
Jan 22, 2015·The British Journal of Surgery·A MuthB Wängberg
Jan 30, 2015·European Journal of Endocrinology·Marianne WeigelMarcus Quinkler

❮ Previous
Next ❯

Citations

Jun 7, 2018·Clinical Endocrinology·Hikaru HashimuraJun Yang
Jul 19, 2018·Journal of Hypertension·Hiroki KobayashiUNKNOWN JPAS Study Group
Jun 25, 2019·Hypertension·Hiroshi AkasakaUNKNOWN Japan Primary Aldosteronism Study Group *
Oct 20, 2019·The Journal of Clinical Endocrinology and Metabolism·Hidekazu NaganoTomoaki Tanaka
Dec 19, 2019·Journal of Hypertension·Troy H PuarPeng C Kek
Apr 29, 2020·Journal of Human Hypertension·Renata LibiantoJun Yang
Jun 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Jacopo BurrelloPaolo Mulatero
Oct 9, 2020·The Journal of Clinical Endocrinology and Metabolism·Youichi OhnoAkiyo Tanabe
Dec 29, 2020·Hypertension·Ryo NakamaruUNKNOWN JPAS/JRAS study group
Jan 14, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Koshiro NishimotoUNKNOWN JRAS Study Group
Sep 6, 2020·Radiology and Oncology·Tomaz KocjanMilenko Stankovic
Apr 30, 2021·Frontiers in Endocrinology·Kentaro OkamotoMitsuhide Naruse

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.