PMID: 15329583Aug 27, 2004Paper

A new closed-loop control system for isoflurane using bispectral index outperforms manual control

Anesthesiology
Stephan LocherA M Zbinden

Abstract

Automatic control of depth of hypnosis using the Bispectral Index (BIS) can help to reduce phases of inadequate control. Automated BIS control with propofol or isoflurane administration via an infusion system has recently been described, a comparable study with isoflurane administration via a vaporizer had not been conducted yet. Our hypothesis was that our new model based closed-loop control system can safely be applied clinically and maintains the BIS within a defined target range better than manual control. Twenty-three patients, American Society of Anesthesiologists risk class I-III, scheduled for decompressive spinal surgery were randomized into groups with either closed-loop or manual control of BIS using isoflurane. An alfentanil target-controlled infusion was adjusted according to standard clinical practice. The BIS target was set to 50 during the operation. The necessity of human intervention in the control system and events of inadequate sedation (BIS <40 or BIS >60) were counted. The number of phases of inadequate control, defined as BIS >/=65 for more than 3 min, were recorded. The performance of the controller was assessed by several indicators (mean absolute deviation and median absolute performance error) and mea...Continue Reading

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Citations

May 29, 2007·Der Anaesthesist·S KreuerT Bouillon
Jun 10, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas M HemmerlingPierre A Mathieu
Aug 20, 2009·Anesthesia and Analgesia·Warren S Sandberg
Dec 16, 2010·Anesthesia and Analgesia·Brett L MooreLarry D Pyeatt
Oct 24, 2013·Anesthesia and Analgesia·Timothy E Miller, Tong J Gan
Jan 1, 2010·Sensors·Bojan Musizza, Samo Ribaric
Jun 19, 2013·Journal of Clinical Monitoring and Computing·Mohamad WehbeThomas M Hemmerling
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Jan 10, 2012·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·J Sethu MadhavanPreethy J Mathew
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