PMID: 2506158Sep 1, 1989Paper

A new combined approach in the conservative management of rectal cancer

International Journal of Radiation Oncology, Biology, Physics
Y OtmezguineM Julien

Abstract

Between 1980 and 1987, 25 patients with rectal cancer were treated with a combination of preoperative external irradiation of 35 Gy in 15 fractions over 3 weeks which was followed, 6 to 8 weeks later, by a tumorectomy and peroperative placement of a plastic tube loop for post-operative interstitial therapy by iridium-192. This boost dose was 20 Gy (Paris System) for submucosal lesions (seven patients) and 25 Gy for intramural (eight patients) and extramural (ten patients) lesions. With a mean follow-up of 40.5 months, there have been five local recurrences, the latest occurring 16 months post-tumorectomy. Two of these five patients are alive and disease-free 1 year post salvage abdominoperineal resection. The 20 patients with local control have preserved a full functional sphincter and 19 of them are disease-free; there were few complications. This sphincter preserving combined approach seems promising for patients with tumors of the middle and lower rectum who cannot undergo major surgery and for selected patients who refuse abdominoperineal resection.

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Citations

Mar 1, 1995·World Journal of Surgery·B J Cummings
Nov 1, 1995·Diseases of the Colon and Rectum·L FortunatoJ P Hoffman
Oct 5, 2001·Diseases of the Colon and Rectum·S Sengupta, J J Tjandra
Sep 7, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Rodrigo O PerezIvan Cecconello
Feb 1, 1995·International Journal of Radiation Oncology, Biology, Physics·B D MinskyP Paty
Sep 25, 1998·International Journal of Radiation Oncology, Biology, Physics·R WagmanP P Paty
Mar 12, 2005·Digestive Surgery·Piero NastroJohn R T Monson
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Mar 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Laval GrimardJohanna N Spaans
Jun 1, 2010·Journal of Surgical Oncology·Kimberly A Varker, Harold J Wanebo
Apr 9, 2005·Surgical Oncology Clinics of North America·Harold J WaneboKimberly A Varker
Sep 1, 1992·Cancer·B J Cummings
Jan 30, 2015·Archives of Pharmacal Research·Vishal Chandra, Kyeong-Man Hong
Jun 8, 2002·Annals of Surgical Oncology·Federico BozzettiPasquale Spinelli

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