PMID: 9450834Feb 5, 1998Paper

A new concept in laryngeal muscle: multiple myosin isoform types in single muscle fibers of the lateral cricoarytenoid

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Y Z WuV J Caiozzo

Abstract

This report describes the first known investigation of canine laryngeal muscle in which single fibers were dissected and their myosin heavy chain (MHC) isoform content was analyzed. Both SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and western blot techniques were used. The data from single fiber SDS-PAGE indicate that the lateral cricoarytenoid (LCA) is predominantly a fast muscle composed of the following MHC isoforms: Type I, 16.3%; Type IIA, 71.3%; Type IIX, 10.4%; and Type IIB, 2.0%. The results reveal a phenomenon that, to our knowledge, has not been previously described for laryngeal muscle: the presence of two or more MHC isoforms in a single canine LCA muscle fiber. A large number (41%) of muscle fibers coexpressed two or more MHC isoforms. The three most common patterns of coexpression were Type IIA/IIX (72%), Type IIA/I (16%), and Type IIA/IIX/I (8%). Interestingly, the fast Type IIX MHC isoform was typically present with other isoforms and rarely found by itself in individual fibers. Additional experiments are underway to determine whether other laryngeal muscles exhibit such an unusually high ratio of MHC isoform polymorphism.

References

Mar 1, 1978·Acta Oto-laryngologica·E TeigH Thorkelsen
Feb 1, 1992·The Annals of Otology, Rhinology & Laryngology. Supplement·L S Zaretsky, I Sanders
Feb 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L Gorza
Jun 1, 1989·Journal of Muscle Research and Cell Motility·S SchiaffinoT Lømo
Mar 1, 1989·Acta Oto-laryngologica·W HappakW Streinzer
Jun 1, 1967·The Annals of Otology, Rhinology, and Laryngology·M H Hast
Oct 1, 1982·Archives of Otolaryngology·D B RosenfieldB M Patten
Sep 1, 1981·The Annals of Otology, Rhinology, and Laryngology·L T Malmgren, R R Gacek
Mar 1, 1995·The Annals of Otology, Rhinology, and Laryngology·J M DelGaudioR M Escalmado
Aug 1, 1994·Journal of Applied Physiology·S Schiaffino, C Reggiani
May 1, 1996·Journal of Applied Physiology·V J CaiozzoK M Baldwin

❮ Previous
Next ❯

Citations

Sep 16, 2005·Cell and Tissue Research·Luz M Acevedo, José-Luis L Rivero
Mar 3, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Zhao-Bo LiPaul W Flint
Jan 11, 2012·Journal of Speech, Language, and Hearing Research : JSLHR·Rebecca S BartlettSusan L Thibeault
Jul 28, 2001·Clinical and Experimental Pharmacology & Physiology·G M Stephenson
Sep 28, 1999·The Laryngoscope·A ShiotaniP W Flint
Jul 9, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hannah S Rhee, Joseph F Y Hoh
Mar 27, 2009·Journal of Voice : Official Journal of the Voice Foundation·Victor J Boucher, Tareck Ayad
Sep 17, 2015·Journal of Biomedical Informatics·Chaitanya ShivadeAlbert M Lai
Jan 29, 2005·Acta Physiologica Scandinavica·J F Y Hoh
Aug 2, 2006·Journal of Anatomy·Malan StrbencGregor Fazarinc
Sep 18, 2008·Journal of Morphology·Vika SmerduGregor Fazarinc
Aug 17, 2005·Journal of Voice : Official Journal of the Voice Foundation·Fariborz AlipourNiro Tayama
Feb 24, 2000·The Annals of Otology, Rhinology, and Laryngology·S PériéG S Butler-Browne
Apr 22, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hannah S RheeJoseph F Y Hoh
Feb 28, 2002·The Annals of Otology, Rhinology, and Laryngology·James J ScioteClark Rosen
Apr 25, 2000·The Annals of Otology, Rhinology, and Laryngology·R L Crumley
Oct 17, 2018·The Laryngoscope·Andrew M Vahabzadeh-HaghDinesh K Chhetri
Dec 1, 2019·The Journal of Experimental Biology·Scott Medler
Dec 24, 2005·American Journal of Physiology. Cell Physiology·Mark BergrinPeter J Reiser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.