A new concept of drug delivery for acne

Dermatology : International Journal for Clinical and Investigative Dermatology
B ShrootN Wagner

Abstract

Adapalene is a stable naphthoic acid derivative that displays a strong retinoid agonist pharmacology. This drug controls cell proliferation and differentiation, and possesses significant anti-inflammatory action. The retinoid action of adapalene are mediated by the ligand-activated gene transcription factors retinoic acid receptors RAR beta and RAR gamma. We describe here how an aqueous gel containing adapalene was selected for the topical treatment of acne.

Citations

Nov 11, 2003·Clinical Pharmacokinetics·Andrea Krautheim, Harald Gollnick

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