A new contraceptive pill containing 17β-estradiol and nomegestrol acetate

Women's Health
S Christin-MaitreLéopoldine Bricaire

Abstract

Most combined oral contraceptive pills contain ethinyl estradiol (EE) with progestins. In order to minimize the pill's cardiovascular risks, the concept of using 17β-estradiol (E2), the endogenous estradiol, arose in the 1970s. Many attempts to develop a pill containing 17β-E2 have failed as cycle control was low. The first pill containing 17β-E2 was launched in 2011. This monophasic pill contains 24 pills with 1.5 mg 17β-E2 and 2.5 mg nomegestrol acetate, and four placebo pills. Studies conducted in Europe and the USA demonstrate that its Pearl index is 0.38 and 1.13, respectively. It has less influence on hemostasis, fibrinolysis markers, lipids and carbohydrate metabolism than the combined oral contraceptive levonorgestrel/EE (150 g/30 g and 100 µg/20 µg). Withdrawal bleedings are shorter and lighter as compared with women using drospirenone/EE (3 mg/ 30 µg). The number of women without withdrawal bleeding is approximately 30% after 12 months. Even though its contraindications are identical to other combined oral contraceptives, this nomegestrol acetate/E2 pill should be considered to be of interest for many women.

References

Mar 1, 1977·American Journal of Obstetrics and Gynecology·R B GreenblattJ R Bryner
Dec 1, 1987·British Journal of Obstetrics and Gynaecology·B BazinJ Paris
Nov 1, 1982·American Journal of Obstetrics and Gynecology·C A MashchakD R Mishell
Nov 1, 1982·American Journal of Surgery·K H Cohn, W Silen
Oct 23, 1998·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·H HoffmannM Oettel
Apr 4, 2002·Contraception·Øjvind Lidegaard, Svend Kreiner
May 2, 2003·Human Reproduction·Nathalie BajosCOCON Group
Dec 1, 1958·Postgraduate Medicine·G PINCUS
Apr 6, 2004·Maturitas·Herjan J T Coelingh Bennink
Apr 28, 2006·Statistics in Medicine·Committee for Medicinal Products for Human UseCommittee for Release for Consultation
Apr 28, 2006·Statistics in Medicine·Committee for Medicinal Products for Human UseCommittee for Release for Consultation
Oct 3, 2006·Obstetrics and Gynecology·Tommaso SimonciniAndrea Riccardo Genazzani
Jun 24, 2008·World Health & Population·Vijayan K Pillai, T S Sunil
Oct 1, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·P MadelenatGroupe de réflexion sur la contraception progestative
May 13, 2009·Maturitas·Adolf E SchindlerJos H H Thijssen
Aug 15, 2009·Drugs·Sheridan M Hoy, Lesley J Scott
Aug 15, 2009·BMJ : British Medical Journal·Øjvind LidegaardCarsten Agger
Oct 12, 2010·Contraception·Regine Sitruk-Ware, Anita Nath
Feb 22, 2011·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·N Chabbert-BuffetS Christin-Maitre
Feb 22, 2011·Steroids·Alfred O Mueck, Regine Sitruk-Ware
Apr 6, 2011·Studies in Family Planning·Susheela SinghRubina Hussain
Jun 17, 2011·World Health & Population·Mousumi Dutta, Zakir Husain
Sep 17, 2011·Contraception·Johannes Bitzer, James A Simon
Oct 15, 2011·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Diana MansourTjeerd Korver
Nov 10, 2011·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Ulla M ÅgrenEllen Mommers
Dec 16, 2011·Clinical Therapeutics·Laura M Borgelt, Chad W Martell
May 12, 2012·BMJ : British Medical Journal·Øjvind LidegaardEllen Løkkegaard
May 25, 2012·The New England Journal of Medicine·Brooke WinnerGina M Secura
Jun 15, 2012·The New England Journal of Medicine·Øjvind LidegaardNiels Keiding

Citations

Aug 12, 2014·Drug and Therapeutics Bulletin
Apr 5, 2017·Hormone Research in Pædiatrics·S Christin-Maitre
Jan 3, 2019·Archiv der Pharmazie·Bao-Cheng XieYun-Sheng Huang
Apr 16, 2016·Journal of Developmental Origins of Health and Disease·A M AshmanK M Rae
Aug 30, 2013·Organic & Biomolecular Chemistry·Wen WanJian Hao
Jun 4, 2014·The Cochrane Database of Systematic Reviews·Jamie Hartmann-BoyceLindsay F Stead
Nov 19, 2018·The Science of the Total Environment·Samuel FekaduBart Van der Bruggen

Methods Mentioned

BETA
contraception
hormone replacement therapy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.