A new coronavirus associated with human respiratory disease in China.

Nature
Fan WuYong-Zhen Zhang

Abstract

Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health1-3. Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. As of 25 January 2020, at least 1,975 cases had been reported since the first patient was hospitalized on 12 December 2019. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan. Here we study a single patient who was a worker at the market and who was admitted to the Central Hospital of Wuhan on 26 December 2019 while experiencing a severe respiratory syndrome that included fever, dizziness and a cough. Metagenomic RNA sequencing4 of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here 'WH-Human 1' coronavirus (and has also been referred to as '2019-nCoV'). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that the virus was most closely related (89.1% nucleotide similarity) to a group of SARS-like cor...Continue Reading

References

Jan 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·D Hamre, J J Procknow
Dec 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·K McIntoshR M Chanock
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Mar 23, 2004·Nature Medicine·Lia van der HoekBen Berkhout
Sep 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susanna K P LauKwok-Yung Yuen
Oct 1, 2005·Science·Wendong LiLin-Fa Wang
Sep 7, 2006·The Journal of Biological Chemistry·William C HwangRobert C Liddington
May 18, 2007·Nature·Nathan D WolfeJared Diamond
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Dec 22, 2009·Bioinformatics·Bo LiColin N Dewey
Aug 28, 2010·Bioinformatics·Darren P MartinPierre Lefeuvre
May 17, 2011·Nature Biotechnology·Manfred G GrabherrAviv Regev
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Jan 19, 2013·Molecular Biology and Evolution·Kazutaka Katoh, Daron M Standley
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Nov 10, 2015·Nature Medicine·Vineet D MenacheryRalph S Baric
Jan 18, 2016·Lancet·Camila V VenturaRubens Belfort
Nov 24, 2016·Nature·Mang ShiYong-Zhen Zhang
Apr 7, 2017·Virology·Xian-Dan LinYong-Zhen Zhang
Apr 6, 2018·Nature·Mang ShiYong-Zhen Zhang
May 23, 2018·Nucleic Acids Research·Andrew WaterhouseTorsten Schwede
Sep 14, 2018·Emerging Microbes & Infections·Dan HuChangjun Wang
Jan 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ruben J G HulswitRaoul J de Groot
Apr 20, 2019·Emerging Infectious Diseases·Pragya D YadavDevendra T Mourya

❮ Previous
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Citations

Feb 15, 2020·Emerging Microbes & Infections·Chuan XiaoFeng Gao
Feb 23, 2020·Radiology·Zi Yue ZuLong Jiang Zhang
Feb 28, 2020·Emerging Microbes & Infections·Shan-Lu LiuLishan Su
Feb 28, 2020·Emerging Microbes & Infections·Weilie ChenXiaoping Tang
Feb 26, 2020·Journal of Medical Virology·Pengfei SunBo Pan
Feb 25, 2020·Journal of Medical Virology·Yi YangXiancai Rao
Mar 3, 2020·Journal of Medical Virology·Qi Lu, Yuan Shi
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Feb 14, 2020·International Journal of Clinical Practice·Richard Albert Stein
Mar 17, 2020·Emerging Microbes & Infections·Jing-Wen AiWen-Hong Zhang
Mar 13, 2020·Journal of Medical Virology·Qing ChenWenzheng Han
Feb 14, 2020·Nature Reviews. Microbiology·Ashley York
Mar 21, 2020·Emerging Microbes & Infections·Michael J Loeffelholz, Yi-Wei Tang
Mar 31, 2020·Alimentary Pharmacology & Therapeutics·Yuan TianYan He
Apr 3, 2020·Journal of Biomolecular Structure & Dynamics·Salman Ali KhanZaheer Ul-Haq
Apr 15, 2020·Human Vaccines & Immunotherapeutics
Mar 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Li GuoJianwei Wang
Mar 31, 2020·Journal of Medical Virology·Andrés E CastilloJorge Fernández
Apr 18, 2020·Current Protocols in Microbiology·Daniel StadlbauerFlorian Krammer
Apr 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tiantian YanGuoan Lin
Mar 14, 2020·Journal of Medical Virology·Changtai WangZhenhua Zhang
Apr 22, 2020·Inflammatory Bowel Diseases·Vincenzo Occhipinti, Luca Pastorelli
Apr 16, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Alice LippiAnita Krisko
Apr 28, 2020·Seminars in Cardiothoracic and Vascular Anesthesia·Linda Y Tang, Jingping Wang
Apr 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Peter ForsterMichael Forster
Apr 23, 2020·Journal of Medical Virology·H C Yashavantha Rao, Chelliah Jayabaskaran
May 1, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Volodymyr V OberemokAnatolii V Kubyshkin
May 1, 2020·International Journal of Environmental Research and Public Health·Giulia Motta ZaninDanilo Spasiano
Apr 21, 2020·Journal of Biomolecular Structure & Dynamics·Subramanian BoopathiPonmalai Kolandaivel
Apr 3, 2020·Journal of Medical Virology·Qing YeTing Zhang
Apr 21, 2020·Journal of Biomolecular Structure & Dynamics·I AanouzM Bouachrine
Apr 19, 2020·Gut·Markus F Neurath
May 1, 2020·Japanese Journal of Infectious Diseases·Kiyoko OkamaotoMakoto Takeda
Apr 23, 2020·Journal of Cellular and Molecular Medicine·Hua LiJunbo Ge
May 7, 2020·Journal of Human Genetics·Kazuma KiyotaniYusuke Nakamura
Apr 19, 2020·Biotechnology Journal·Suh-Chin Wu

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Datasets Mentioned

BETA
MG772933
—that
MN908947
AY274119

Methods Mentioned

BETA
PCR
bronchoalveolar
lavage
reverse-transcription PCR
RNA-Seq

Software Mentioned

Bowtie2
ProMod3
RSEM
PhyML
Trimmomatic
DNAstar
BLAST
BootScan
3SEQ
Recombination Detection Program

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