A new crystal form of human diamine oxidase.

Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
Aaron P McGrathJ Mitchell Guss

Abstract

Copper amine oxidases (CAOs) are ubiquitous in nature and catalyse the oxidative deamination of primary amines to the corresponding aldehydes. Humans have three viable CAO genes (AOC1-3). AOC1 encodes human diamine oxidase (hDAO), which is the frontline enzyme for histamine metabolism. hDAO is unique among CAOs in that it has a distinct substrate preference for diamines. The structure of hDAO in space group P2(1)2(1)2(1) with two molecules in the asymmetric unit has recently been reported. Here, the structure of hDAO refined to 2.1 A resolution in space group C222(1) with one molecule in the asymmetric unit is reported.

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Citations

Jan 11, 2014·Archives of Biochemistry and Biophysics·Joel FinneyMinae Mure
Dec 9, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Karin ErnbergJ Mitchell Guss
Mar 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Serhii VakalTiina A Salminen
Dec 1, 2017·The Journal of Biological Chemistry·Elisabeth GludovaczThomas Boehm
Jul 28, 2019·Molecular Phylogenetics and Evolution·Leonor Lopes de CarvalhoTiina A Salminen

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