A new dawn for eosinophils in the tumour microenvironment.

Nature Reviews. Cancer
Sharon Grisaru-TalAriel Munitz

Abstract

Eosinophils are evolutionarily conserved, pleotropic cells that display key effector functions in allergic diseases, such as asthma. Nonetheless, eosinophils infiltrate multiple tumours and are equipped to regulate tumour progression either directly by interacting with tumour cells or indirectly by shaping the tumour microenvironment (TME). Eosinophils can readily respond to diverse stimuli and are capable of synthesizing and secreting a large range of molecules, including unique granule proteins that can potentially kill tumour cells. Alternatively, they can secrete pro-angiogenic and matrix-remodelling soluble mediators that could promote tumour growth. Herein, we aim to comprehensively outline basic eosinophil biology that is directly related to their activity in the TME. We discuss the mechanisms of eosinophil homing to the TME and examine their diverse pro-tumorigenic and antitumorigenic functions. Finally, we present emerging data regarding eosinophils as predictive biomarkers and effector cells in immunotherapy, especially in response to immune checkpoint blockade therapy, and highlight outstanding questions for future basic and clinical cancer research.

References

Jun 1, 1978·The Journal of Cell Biology·D M LewisG J Gleich
Jul 1, 1990·The Journal of Allergy and Clinical Immunology·K HisamatsuH Koyama
Nov 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A EgestenI Olsson
Oct 1, 1985·The Journal of Allergy and Clinical Immunology·G H AyarsC B Baker
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L J Yaffe, F D Finkelman
May 1, 1984·Journal of Clinical Pathology·D LoweR L Gower
Oct 1, 1995·The Journal of Experimental Medicine·P D CollinsT J Williams
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M E RothenbergP Leder
Jul 14, 1995·The Journal of Biological Chemistry·C CombadiereP M Murphy
Nov 1, 1994·American Journal of Surgery·A C ThompsonN R Griffin
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·K KhazaieV Schirrmacher
Apr 22, 1993·International Journal of Cancer. Journal International Du Cancer·L RivoltiniG Parmiani
May 1, 1996·The Journal of Experimental Medicine·B L DaughertyM S Springer
Jun 1, 1996·The Journal of Experimental Medicine·P D PonathC R Mackay
Dec 22, 1998·The Journal of Experimental Medicine·K HungH Levitsky
May 4, 1999·International Archives of Allergy and Immunology·H KuboG J Gleich
Mar 1, 2000·Oral Oncology·D T WongP F Weller
Nov 4, 2000·Expert Opinion on Investigational Drugs·C P Bertrand, P D Ponath
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J C MacPhersonS L Hazen
Oct 9, 2001·The Journal of Allergy and Clinical Immunology·S M PopeM E Rothenberg
Mar 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Gregory W SpiegelJohn J S Brooks
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Nives Zimmermann, Marc E Rothenberg
Feb 5, 2003·The Journal of Experimental Medicine·Joerg MattesChristopher Parish
Apr 3, 2003·European Journal of Immunology·Hans-Uwe SimonFrancesca Levi-Schaffer
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Ming YangPaul S Foster
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Solomon O OdemuyiwaRedwan Moqbel
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ariel MunitzFrancesca Levi-Schaffer
Dec 25, 2004·The International Journal of Biochemistry & Cell Biology·Ilaria PuxedduFrancesca Levi-Schaffer

❮ Previous
Next ❯

Citations

Dec 2, 2020·International Journal of Molecular Sciences·Melanie KienzlRudolf Schicho
Nov 26, 2020·Cancers·Enrico MaggiFrancesco Annunziato
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Maria M HaykalOcéane C B Martin
Apr 24, 2021·Seminars in Immunopathology·Fei Li Kuang, Bruce S Bochner
Mar 2, 2021·Annual Review of Immunology·Elizabeth A JacobsenMarc E Rothenberg
May 1, 2021·Cancers·Yang ZhaoJennifer Gamble
Jun 5, 2021·Nature Reviews. Cancer·Daria BriukhovetskaSebastian Kobold
Jun 3, 2021·Cells·Mariantonia BraileStefania Loffredo
Jun 26, 2021·Cancer Immunology, Immunotherapy : CII·Eiji TakeuchiTsutomu Shinohara
Jul 3, 2021·International Journal of Molecular Sciences·José M Rodrigo-MuñozVictoria Del Pozo
Aug 19, 2021·Journal of Hematology & Oncology·Yingyue LiuXin Wang
Aug 28, 2021·Cancers·Pere Llinàs-AriasDiego M Marzese
Aug 26, 2021·Cancer Research·Sharon Grisaru-TalAriel Munitz
Oct 27, 2021·Journal of Internal Medicine·Yuval TalAlon Y Hershko
Nov 13, 2021·Expert Review of Clinical Immunology·David Watchorn, Fernando Holguin

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
flow cytometry
single-cell sequencing
biopsy
transmission electron microscopy

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Related Papers

Advances in Experimental Medicine and Biology
Fabrizio MatteiGiovanna Schiavoni
Advances in Experimental Medicine and Biology
J K H LemanR A Kemp
© 2021 Meta ULC. All rights reserved