A New Decision Tree to Solve the Puzzle of Alzheimer's Disease Pathogenesis Through Standard Diagnosis Scoring System

Interdisciplinary Sciences, Computational Life Sciences
Ashwani Kumar, Tiratha Raj Singh

Abstract

Alzheimer's disease (AD) is a progressive, incurable and terminal neurodegenerative disorder of the brain and is associated with mutations in amyloid precursor protein, presenilin 1, presenilin 2 or apolipoprotein E, but its underlying mechanisms are still not fully understood. Healthcare sector is generating a large amount of information corresponding to diagnosis, disease identification and treatment of an individual. Mining knowledge and providing scientific decision-making for the diagnosis and treatment of disease from the clinical dataset are therefore increasingly becoming necessary. The current study deals with the construction of classifiers that can be human readable as well as robust in performance for gene dataset of AD using a decision tree. Models of classification for different AD genes were generated according to Mini-Mental State Examination scores and all other vital parameters to achieve the identification of the expression level of different proteins of disorder that may possibly determine the involvement of genes in various AD pathogenesis pathways. The effectiveness of decision tree in AD diagnosis is determined by information gain with confidence value (0.96), specificity (92 %), sensitivity (98 %) and ac...Continue Reading

References

Sep 1, 1992·Journal of the American Geriatrics Society·T N Tombaugh, N J McIntyre
Apr 1, 1984·Annals of Neurology·A HeymanT Weinberg
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Aug 10, 2000·Medical Decision Making : an International Journal of the Society for Medical Decision Making·G J Jager, J L Severens
Sep 2, 2000·Current Opinion in Neurology·J F Dartigues, L Letenneur
Nov 13, 2008·Cognitive Neurodynamics·Lubica Benuskova, Nikola Kasabov
Aug 5, 2010·Archives of Medical Research·Ricardo B MaccioniLeonardo Navarrete
Nov 20, 2012·Current Opinion in Neurology·Heiko Braak, Kelly Del Tredici
Dec 12, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Kie HonjoNicolaas P L G Verhoeff
Sep 7, 2013·Alzheimer's Research & Therapy·Marc Wortmann
May 14, 2014·Journal of Theoretical Biology·Sonia L Mestizo GutiérrezGonzalo E Aranda-Abreu
Jul 29, 2015·Amino Acids·Damiano PiovesanSilvio C E Tosatto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.