A new description of cellular quiescence

PLoS Biology
Hilary A CollerJames M Roberts

Abstract

Cellular quiescence, defined as reversible growth/proliferation arrest, is thought to represent a homogenous state induced by diverse anti-mitogenic signals. We used transcriptional profiling to characterize human diploid fibroblasts that exited the cell cycle after exposure to three independent signals--mitogen withdrawal, contact inhibition, and loss of adhesion. We show here that each signal caused regulation of a unique set of genes known to be important for cessation of growth and division. Therefore, contrary to expectation, cells enter different quiescent states that are determined by the initiating signal. However, underlying this diversity we discovered a set of genes whose specific expression in non-dividing cells was signal-independent, and therefore representative of quiescence per se, rather than the signal that induced it. This fibroblast "quiescence program" contained genes that enforced the non-dividing state, and ensured the reversibility of the cell cycle arrest. We further demonstrate that one mechanism by which the reversibility of quiescence is insured is the suppression of terminal differentiation. Expression of the quiescence program was not simply a downstream consequence of exit from the cell cycle, bec...Continue Reading

References

Jul 1, 1977·Experimental Cell Research·S R Dienstman, H Holtzer
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H WeintraubA D Miller
Dec 1, 1974·Experimental Cell Research·L H Augenlicht, R Baserga
Apr 1, 1969·Developmental Biology·M Nameroff, H Holtzer
Apr 20, 1995·Nature·T ChittendenB C Guild
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S M HollenbergH Weintraub
Sep 3, 1998·The Journal of Biological Chemistry·S MandrupK Kristiansen
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Jun 9, 1999·International Journal of Cancer. Journal International Du Cancer·I Urbanowicz-KachnowiczM Ffrench
Mar 10, 2000·Biochemical and Biophysical Research Communications·D CoppockD A Cina-Poppe
Oct 13, 2001·Genome Biology·P Pavlidis, W S Noble
Oct 13, 2001·Cancer·C G Varricchio, J Stevens
Apr 16, 2002·Science·Wolfgang EnardSvante Pääbo
Jun 12, 2002·Molecular Biology of the Cell·Michael L WhitfieldDavid Botstein
Aug 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Maximilian DiehnPatrick O Brown
Dec 12, 2002·The Journal of Biological Chemistry·Violeta SerraGabriele Saretzki
Jan 30, 2003·Oncogene·Olivier Albagli-Curiel
Mar 26, 2003·Seminars in Cancer Biology·Anning Lin, Michael Karin
Apr 30, 2003·Nature Cell Biology·Laura L SmithJames M Roberts
Sep 4, 2003·Connective Tissue Research·S El-MaadawyM D McKee
Dec 19, 2003·Nucleic Acids Research·Evelyn CamonRolf Apweiler
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chang-Goo HuhSnorri S Thorgeirsson
Jun 8, 2004·Bioinformatics·Alok J Saldanha
Sep 3, 2004·Cancer Research·Jingsong ZhangTimothy J Triche
Oct 2, 2004·PLoS Biology·Teresa A VeneziaMargaret A Goodell
Mar 31, 2005·Cancer Letters·Marine FaussillonCécile Jeanpierre
Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers

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Citations

Aug 31, 2013·Journal of Mathematical Biology·Niklas Hartung
May 21, 2014·Current Opinion in Oncology·James A DeCaprio, Anette Duensing
Jun 7, 2014·Interface Focus·Guang Yao
Sep 3, 2014·International Journal of Genomics·Ayla Valinezhad OrangMina Kazemzadeh-Bavili
Nov 27, 2014·Japanese Journal of Clinical Oncology·Hugh S ColvinHideshi Ishii
Oct 26, 2012·Clinical & Developmental Immunology·Kyle K PayneMasoud H Manjili
Sep 28, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sooncheol LeeShobha Vasudevan
Jun 15, 2007·PLoS Genetics·Helen LiuHoward Y Chang
Oct 25, 2007·Nature Reviews. Cancer·Julio A Aguirre-Ghiso
Nov 19, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Inmaculada M Berenjeno, Xose R Bustelo
Feb 26, 2009·Journal of Mammary Gland Biology and Neoplasia·David C Harmes, James DiRenzo
Mar 25, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Judith Barrios, Robert Wieder
Jun 10, 2009·BMC Genomics·Magdalena ChechlinskaJan Steffen
May 14, 2010·The Journal of Biological Chemistry·Azadeh Jadali, Soosan Ghazizadeh
Nov 5, 2010·PLoS Biology·Johanna M S LemonsHilary A Coller
May 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Richard D MortensenShobha Vasudevan
Jul 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ipsita Dey-GuhaSridhar Ramaswamy
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shibani MukherjeeJames M Roberts
Jun 7, 2012·Cellular and Molecular Life Sciences : CMLS·Kanchan PhadwalAnna Katharina Simon
Jun 14, 2012·PloS One·Takeshi YamadaH Daniel Lacorazza
Mar 14, 2013·The Journal of Biological Chemistry·Adam G EverttsBenjamin A Garcia
Oct 22, 2013·PloS One·Jonathan CroweJonathan L E Dean
Jul 10, 2007·In Vitro Cellular & Developmental Biology. Animal·Ximena A Lanosa, Jorge A Colombo
Nov 8, 2013·Canadian Journal of Zoology·T P YoshinoC J Bayne
Jul 24, 2013·Nature Reviews. Molecular Cell Biology·Cosetta BertoliRobertus A M de Bruin
Nov 26, 2011·Science·Hilary A Coller
Sep 11, 2012·Nature Medicine·Yoshinori FukazawaLouis J Picker
Feb 26, 2008·Histochemistry and Cell Biology·Giacomo DiazAngela Maria Falchi
Sep 12, 2013·Cellular Reprogramming·D N Wells
Sep 21, 2013·DNA Repair·Mario Moscariello, George Iliakis

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Methods Mentioned

BETA
FACS
chip
chips
PCR

Software Mentioned

Affymetrix Genechip suite
Java Treeview
Affymetrix suite
GENECHIP
Genechip suite
Phylip

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