A new drug nanocarrier consisting of chitosan and hydoxypropylcyclodextrin

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Francesca MaestrelliM J Alonso

Abstract

The objective of the present work was to develop a new drug nanocarrier consisting of nanoparticles made of chitosan and cyclodextrins. The rationale behind the design of this new nanosystem was to simultaneously implement the cyclodextrin drug complexation power and the inherent properties of chitosan nanoparticles, in a unique delivery system. The complexation with the cyclodextrin permits the solubilization as well as the protection for sensitive drugs, whereas the entrapment in the chitosan network is expected to facilitate their absorption. Chitosan nanoparticles including hydroxypropylcyclodextrins could be prepared by the ionic crosslinking of chitosan with sodium tripolyphosphate in the presence of cyclodextrins. Two hydrophobic drugs, triclosan and furosemide, were selected as models for complexation with the cyclodextrin and further entrapment in the chitosan nanocarrier. The resulting nanosystems were thoroughly characterized for their size and zeta potential and also for their ability to associate and deliver the complexed drugs. The results showed that the size of the nanoparticles was slightly affected by the incorporation of cyclodextrins, whereas the zeta potential did not suffer a significant modification. More...Continue Reading

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Citations

Dec 25, 2009·Journal of Materials Science. Materials in Medicine·Ana GârleaM I Popa
Apr 24, 2008·AAPS PharmSciTech·W J TricklerA K Dash
Nov 26, 2008·Nanomedicine·Maria de la FuenteMaria Jose Alonso
Apr 5, 2014·Colloids and Surfaces. B, Biointerfaces·Amirali PopatChengzhong Yu
Sep 26, 2014·Nanomedicine·Stephanie Deshayes, Ruxandra Gref
Jul 2, 2014·Nanomedicine·Jaya Raju Lakkakula, Rui Werner Maçedo Krause
Oct 31, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eunae Cho, Seunho Jung
May 26, 2010·Journal of Drug Targeting·A L Laza-KnoerrP Couvreur
Dec 23, 2010·Expert Opinion on Drug Delivery·Lisa C du ToitTrevor Carmichael
Jul 11, 2006·Expert Opinion on Drug Delivery·Noémi CsabaMaría José Alonso
Aug 27, 2009·Expert Opinion on Drug Delivery·Erem Bilensoy, A Atilla Hincal
Apr 7, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marcos Garcia-Fuentes, Maria J Alonso
Feb 8, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Clara Luisa Domínguez-DelgadoAdriana Ganem
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Maite AgüerosJuan Manuel Irache
Jan 6, 2009·Advanced Drug Delivery Reviews·Noemi CsabaMaria Jose Alonso
Dec 5, 2009·Advanced Drug Delivery Reviews·Maria de la FuenteMaria Jose Alonso
Jul 10, 2016·Drug Delivery and Translational Research·Sonia Reimondez-TroitiñoMaría J Alonso
May 30, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yongli ZhengXizhong Shen
Apr 11, 2017·Advanced Drug Delivery Reviews·Dileep R JanagamTao L Lowe
Jan 16, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Diego A ChiappettaAlejandro Sosnik
May 7, 2008·Nanotechnology·A TrapaniM J Alonso
Feb 2, 2010·Journal of Microencapsulation·Paola MuraAntonio Almeida
Jan 2, 2009·Biomacromolecules·Desirée Teijeiro-OsorioMaría José Alonso
Jan 11, 2011·Journal of Pharmaceutical and Biomedical Analysis·Mario JugPaola Mura
Mar 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F MaestrelliP Mura

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