A new drug-release method using the Staudinger ligation

Bioorganic & Medicinal Chemistry Letters
Michel AzoulayJean-Claude Florent

Abstract

Many drugs induce severe side-effects caused by their lack of selectivity. One way to overcome this problem is to design a specific system which releases a free drug in a controlled manner. Herein we describe a new way to liberate a drug from a prodrug using the Staudinger ligation as the trigger.

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Citations

Dec 16, 2006·The Journal of Organic Chemistry·Matthew B SoellnerRonald T Raines
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