PMID: 16640847Apr 28, 2006Paper

A new DTPw-HB/Hib combination vaccine for primary and booster vaccination of infants in Latin America

Revista Panamericana De Salud Pública = Pan American Journal of Public Health
Miguel TregnaghiLode Schuerman

Abstract

In 1998 the World Health Organization (WHO) recommended the inclusion of Haemophilus influenza type B (Hib) conjugate vaccines in infant immunization programs, whenever in accordance with national priorities. GlaxoSmithKline Biologicals has developed a new pentavalent combined diphtheria-tetanus-whole cell pertussis-hepatitis B/Hib (DTPw-HB/Hib) vaccine containing 5 microg of polyribosylribitol phosphate (PRP), and we assessed the immunogenicity and reactogenicity of primary and booster vaccination of healthy children with this new vaccine compared with a reference regimen consisting of the licensed DTPw-HB (Tritanrix) and Hib (Hiberix) vaccines given as simultaneous concomitant injections. We performed a randomized, double-blind study from September 1998 to August 1999 to establish the immunogenicity and reactogenicity of primary and booster vaccination of healthy children with the new pentavalent combined DTPw-HB/Hib vaccine given as a single injection, compared with the reference regimen. Both vaccination regimens elicited excellent immune responses, with all subjects in both groups achieving seroprotective anti-PRP antibody concentrations of > or = 0.15 microg/mL one month after primary vaccination. The combined DTPw-HB/Hib...Continue Reading

Citations

Mar 21, 2008·Expert Opinion on Biological Therapy·Roman Prymula, Stanislav Plisek
Jun 14, 2016·Human Vaccines & Immunotherapeutics·Ian F Cook
Jun 7, 2017·Pharmacoepidemiology and Drug Safety·Ayebo Evawere SadohWilson Ehidiamen Sadoh
Aug 31, 2006·Current Opinion in Infectious Diseases·Jane N Zuckerman
Apr 6, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Alexander N O DodooAugustina Appiah-Danquah

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