A new dynamic index of insulin sensitivity

IEEE Transactions on Bio-medical Engineering
Gianluigi PillonettoC Cobelli

Abstract

Insulin sensitivity is a crucial parameter of glucose metabolism. The standard measures of insulin sensitivity obtained by an euglycaemic hyperinsulinaemic clamp, Si(clamp), or by the minimal model (MM), SI, do not account for the dynamics of insulin action, i.e., how fast or slow insulin action reaches its plateau value. This is an important physiological information. In this paper we formally define a new insulin sensitivity index which also incorporates information on the dynamics of insulin action, SD(I), show its properties, and exemplify how it can be measured both with the clamp and the MM method. Then, by resorting to real and synthetic data, we show both in IVGTT MM and clamp studies why this new index SD(I) offers, in comparison with SI, a more comprehensive picture of the control of insulin on glucose.

References

Nov 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·A CaumoC Cobelli
May 1, 1974·The Journal of Clinical Investigation·R S SherwinR Andres
Jan 1, 1995·Lifetime Data Analysis·K Y LiangS L Zeger
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Gianluigi PillonettoClaudio Cobelli

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Citations

Mar 31, 2011·Medical & Biological Engineering & Computing·Roberto BurattiniMassimo Boemi
Aug 8, 2013·Diabetes Technology & Therapeutics·Claudia EberleChristoph Ament
Nov 19, 2009·American Journal of Physiology. Endocrinology and Metabolism·Gianluigi PillonettoClaudio Cobelli
Mar 20, 2010·Theoretical Biology & Medical Modelling·Simona PanunziGeltrude Mingrone
Oct 13, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M Matsuda
Apr 25, 2014·IEEE Transactions on Bio-medical Engineering·Claudio CobelliGianna Toffolo
Mar 22, 2014·Diabetes·Claudio CobelliRobert Rizza
Apr 27, 2016·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Mairéad Bracken-ScallyJeffrey T Mitchell
Feb 22, 2007·American Journal of Physiology. Endocrinology and Metabolism·K ThomasethB Ahrén
Jun 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ray C Boston, Peter J Moate

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