A new effect residual ratio (ERR) method for the validation of the concentration addition and independent action models.

Environmental Science and Pollution Research International
Li-Juan WangWei-Ying Li

Abstract

Glutaraldehyde (GA) often acts as an effective sterilant, disinfectant, and preservative in chemical products. It was found that GA had clearly acute toxicity to aquatic organisms. Furthermore, GA in natural environment could not exist as single species but as complex mixtures. To explore the toxicity interaction between GA and the other environmental pollutant, it is necessary to determine the mixture toxicities of various binary mixtures including GA. Two reference models, concentration addition (CA) and independent action (IA), are often employed to evaluate the mixture toxicity, which can be finished by comparing the concentration-response curves (CRCs) predicted by the reference models with the experimental CRC of the mixture. However, the CRC-based method cannot effectively denote the degree of the deviations from the reference models, especially at very low effect levels. Though the model deviation ratio (MDR) can be used to quantitatively evaluate the deviation of a mixture at EC50 level from the reference model, it is difficult to evaluate the deviations at the lower effect levels. Therefore, the primary aim of this study was to develop a new effect residual ratio (ERR) method to validate the deviations from the refere...Continue Reading

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Citations

Nov 26, 2010·Environmental Science and Pollution Research International·Rong-Ni DouFu-Cai Deng
May 27, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui-Lin GeXiang-Wei Zhu

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