PMID: 6983509Oct 1, 1982Paper

A new electrochemical approach for the in vitro investigation of damage in native DNA by small gamma-radiation doses

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
J M SéquarisH W Nürnberg

Abstract

Voltammetry provides a new method to assess gamma-radiation damage to native DNA in vitro after low doses of irradiation. Using single sweep voltammetry at a stationary mercury electrode a substantial labilization of the double helical conformation of gamma-irradiated DNA was found. Up to 40 Gy a linear dose-effect relationship exists reflected for the number of strand breaks and the number of destabilized base pairs. A considerable difference in the frequency of formation of the two kinds of radiation damage is seen in the ratio of their G-values. Base pair labilization occurs depending on aeration conditions 200 to 300 times more frequently than the formation of a single strand break.

References

Oct 28, 1974·Biophysics of Structure and Mechanism·P Valenta, H W Nürnberg
Jan 1, 1972·Annual Review of Biophysics and Bioengineering·R B Setlow, J K Setlow
Jan 1, 1972·Annual Review of Biochemistry·P H Von Hippel, J D McGhee
Jan 17, 1973·Nature: New Biology·R Saffhill, J J Weiss
Jun 10, 1974·Radiation and Environmental Biophysics·R Frey, U Hagen
Jan 1, 1970·Biochimica Et Biophysica Acta·A Bopp, U Hagen
Jan 1, 1964·Progress in Nucleic Acid Research and Molecular Biology·J J Weiss
Mar 1, 1980·Ecotoxicology and Environmental Safety·L SantiC Bolognesi
Feb 1, 1965·Journal of Molecular Biology·F W STUDIER

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