PMID: 12174Dec 10, 1976

A new endoribonuclease from Escherichia coli. Ribonuclease N

The Journal of Biological Chemistry
T K MisraD Apirion


A new ribonuclease called RNase N was isolated from Escherichia coli. It is a nonspecific endoribonuclease that can cleave rRNA, poly(U), and poly(C) to small oligonucleotides and 5'-mononucleotides. It requires monovalent cations and is inhibited by divalent cations. It is suggested that this enzyme plays a role in the decay of rRNA,under various starvation conditions and perhaps in the decay of mRNA.

Related Concepts

Cations, Monovalent
Alkalescens-Dispar Group
Hydrogen-Ion Concentration
Alkaline Ribonuclease

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