A new entry to highly functionalized pyrroles via a cascade reaction of α-amino esters and alkynals

Chemical Communications : Chem Comm
Liang WeiChun-Jiang Wang

Abstract

Here, we developed an expedient access route to highly functionalized pyrroles from readily available α-amino acid ester hydrochlorides and alkynals via a cascade condensation/intramolecular cyclization followed by a unique C-N ester migration process. A variety of 1,2,3-trisubstituted pyrroles, which were difficult to acquire with the common methodologies, were successfully prepared in good yields under mild conditions.

References

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Apr 23, 2020·Accounts of Chemical Research·Liang WeiChun-Jiang Wang

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