A new extra sequence at the amino terminal of a mu heavy chain disease protein (DAG)

Molecular Immunology
C MihaescoE Mihaesco

Abstract

The primary structure of a human mu heavy chain (DAG) protein is described. The native protein is a circular decamer with a molecular weight (Mr) of 500 kDa, each decamer being constituted of the constant domains C mu 2, C mu 3 and C mu4 and interlinked by 15 disulfide bridges. At its NH2-terminal each monomeric chain starts with an "extra sequence". The amino acid sequence of this segment is Arg-Gln-Ser-Asp-Asp-Pro-Val-Leu-Arg-Gly-Thr-Thr-Val-Pro-Val-Thr-Glu and its reinitiation point is located at Val223 (Gal numbering), at the beginning of C mu 2. This sequence has no homology with any other protein included in the present databases.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A AlexanderJ Buxbaum
Jan 1, 1979·Immunological Reviews·M SeligmannJ C Brouet
Aug 1, 1975·Scandinavian Journal of Haematology·F DanonM Seligmann
Jan 1, 1976·Immunochemistry·C MihaescoM Seligmann
Mar 1, 1975·European Journal of Immunology·J P LebretonG Biserte
Jun 1, 1989·Research in Immunology·M CognéP Guglielmi
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A BakhshiS J Korsmeyer
Jul 1, 1986·Molecular Immunology·A BakhshiS J Korsmeyer
Dec 1, 1973·FEBS Letters·C MihaescoH Metzger
Jul 1, 1974·Analytical Biochemistry·B PenkeK Kovács
Dec 7, 1984·Journal of Chromatography·B A BidlingmeyerT L Tarvin
Aug 1, 1983·Scandinavian Journal of Immunology·E MihaescoC Mihaesco
Jan 1, 1984·Hoppe-Seyler's Zeitschrift für physiologische Chemie·S Barnikol-WatanabeN Hilschmann
Sep 1, 1964·The American Journal of Medicine·E C FRANKLINM MELTZER

❮ Previous
Next ❯

Citations

Jun 19, 2004·Hematology·Koji KinoshitaAkihisa Kanamaru
Jan 1, 1992·International Journal of Clinical & Laboratory Research·J C BrouetA Tsapis
May 1, 1992·American Journal of Hematology·D L Wahner-Roedler, R A Kyle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved