A New Extrudable Form of Hypromellose: AFFINISOL™ HPMC HME

AAPS PharmSciTech
Siyuan HuangRobert O Williams

Abstract

Hypromellose is a hydrophilic polymer widely used in immediate- and modified-release oral pharmaceutical dosage forms. However, currently available grades of hypromellose are difficult, if not impossible, to process by hot melt extrusion (HME) because of their high glass transition temperature, high melt viscosity, and low degradation temperature. To overcome these challenges, a modified grade of hypromellose, AFFINISOL™ HPMC HME, was recently introduced. It has a significantly lower glass transition temperature and melt viscosity as compared to other available grades of hypromellose. The objective of this paper is to assess the extrudability and performance of AFFINISOL™ HPMC HME (100LV and 4M) as compared to other widely used polymers in HME, including HPMC 2910 100cP (the currently available hypromellose), Soluplus®, Kollidon® VA 64, and EUDRAGIT® E PO. Formulations containing polymer and carbamazepine (CBZ) were extruded on a co-rotating 16-mm twin-screw extruder, and the effect of temperature, screw speed, and feed rate was investigated. The performance of the solid dispersions was evaluated based on Flory-Huggins modeling and characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), Raman s...Continue Reading

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Citations

Feb 11, 2016·AAPS PharmSciTech·Feng Zhang, Michael A Repka
Jan 31, 2016·Advanced Drug Delivery Reviews·Teófilo VasconcelosBruno Sarmento
Aug 27, 2015·AAPS PharmSciTech·Justin S LaFountaineRobert O Williams
Oct 21, 2016·Drug Development and Industrial Pharmacy·Soraya Hengsawas SurasarangRobert O Williams
May 20, 2017·Pharmaceutical Research·Khadijah EduengChristel A S Bergström
Sep 20, 2017·AAPS PharmSciTech·Siyuan Huang, Robert O Williams
Mar 22, 2019·The British Journal of Sociology·Ahmad Mohammadpour, Kamal Soleimani
Mar 15, 2020·International Journal of Molecular Sciences·Casati FedericaGazzaniga Andrea
May 8, 2018·AAPS PharmSciTech·Fatemeh Rezaee, Fariba Ganji
Sep 19, 2020·Drug Development and Industrial Pharmacy·Hao WuXue Ke
Aug 23, 2020·Pharmaceutics·Ana Luiza LimaMarcilio Cunha-Filho
Feb 5, 2021·International Journal of Pharmaceutics·Kejing ShiAli Nokhodchi
May 27, 2021·Drug Development and Industrial Pharmacy·Dnyaneshwar N Kapote, Karl G Wagner
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Nov 13, 2020·Current Drug Delivery·Sanjeevani DeshkarKrishnakant Gandhi

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