A new formula for predicting liver metastasis in patients with colorectal cancer: immunohistochemical analysis of a large series of 439 surgically resected cases

Oncology
Hiroki OchiaiSetsuo Hirohashi

Abstract

The purpose of this study was to establish a new formula predicting liver metastasis in patients with colorectal cancer (CRC). Nine previously reported predictive markers for liver metastasis and/or prognosis (COX-2, dysadherin, E-cadherin, beta-catenin, Ki-67, p53, laminin5gamma2, matrilysin and MUC-1) were immunohistochemically investigated in 439 consecutive patients with CRC. We tried to determine the combination of molecules which best predicted liver metastasis. A formula for predicting liver metastasis was constructed using a training cohort comprising 150 cases, and applied to a validation cohort comprising 190 cases and another comprising 99 cases from an outside hospital. A combination of dysadherin, E-cadherin and matrilysin was identified to be best for predicting liver metastasis (area under the curve value, 0.807). The predictive formula: 3x dysadherin score [0 for low expression (</=50% of tumor cells positive) or 1 for high expression (>50%)] + 4x E-cadherin score [0 for preserved (>80% of tumor cells positive) or 1 for reduced (</=80%)] + 2x matrilysin score [0 for low expression (</=30% of tumor cells positive) or 1 for high expression (>30%)] was able to discriminate patients with liver metastasis in the trai...Continue Reading

Citations

Mar 20, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Johanna MrenaCaj Haglund
Mar 10, 2011·Future Oncology·Anand Govindarajan, Philip B Paty
Mar 21, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Arpad IvaneczStojan Potrč
Jun 22, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Adam ElzagheidSeppo Pyrhönen
Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Yin-Lu DingLei Xiang
Jul 15, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zbigniew LorencUrszula Mazurek
Jun 28, 2011·The American Journal of Pathology·Lichao SunYuliang Ran

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