A new formulation of Gamma Delta Tocotrienol has superior bioavailability compared to existing Tocotrienol-Rich Fraction in healthy human subjects

Scientific Reports
Puvaneswari MeganathanZ Chik

Abstract

Gamma and delta tocotrienols are isomers of Vitamin E with established potency in pre-clinical anti-cancer research. This single-dose, randomized, crossover study aimed to compare the safety and bioavailability of a new formulation of Gamma Delta Tocotrienol (GDT) in comparison with the existing Tocotrienol-rich Fraction (TRF) in terms of gamma and delta isomers in healthy volunteers. Subjects were given either two 300 mg GDT (450 mg γ-T3 and 150 mg δ-T3) capsules or four 200 mg TRF (451.2 mg γ-T3 &102.72 mg δ-T3) capsules and blood samples were taken at several time points over 24 hours. Plasma tocotrienol concentrations were determined using HPLC method. The 90% CI for gamma and delta tocotrienols for the ratio of log-transformation of GDT/TRF for Cmax and AUC0-∞ (values were anti-logged and expressed as a percentage) were beyond the bioequivalence limits (106.21-195.46, 154.11-195.93 and 52.35-99.66, 74.82-89.44 respectively). The Wilcoxon Signed Rank Test for Tmax did not show any significant difference between GDT and TRF for both isomers (p > 0.05). No adverse events were reported during the entire period of study. GDT was found not bioequivalent to TRF, in terms of AUC and Cmax. Gamma tocotrienol in GDT showed superior b...Continue Reading

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Citations

May 3, 2016·The Journal of Nutritional Biochemistry·Weiming Xia, Huanbiao Mo
Mar 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lu ZhaoSoonkyu Chung
Oct 30, 2016·International Journal of Molecular Sciences·Puvaneswari Meganathan, Ju-Yen Fu
Oct 4, 2017·Nanomedicine·Doryn Meam-Yee TanKalanithi Nesaretnam
Jan 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Spencer AsayJason D Kenealey
Nov 1, 2020·Molecular and Cellular Biochemistry·Maria JanubovaIngrid Zitnanova
Dec 17, 2020·International Journal of Nanomedicine·Anis Syauqina Mohd ZaffarinEkram Alias

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Methods Mentioned

BETA
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Clinical Trials Mentioned

NCT01571921

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WinNonlin Professional
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