A new frame in thromboembolic cardiovascular disease: Adipocytokine

International Journal of Cardiology
Basri AmasyaliAtila Iyisoy

Abstract

Recent researches have shown that adipocytokines secreted by adipose tissue play an important role in inflammation which is considered to be a crucial step in the pathogenesis of atherosclerosis. Leptin, one of the earlier adipocytokines, is known to play a major role in cardiovascular disease and recent observations suggest that leptin is an independent risk factor for coronary heart disease. Resistin, another recently discovered adipocytokine, has been related to risk factors of atherosclerosis, and in diabetic individuals serum resistin levels correlate well with inflammatory markers and are predictive for the development of cardiovascular disease. Adiponectin, another adipocytokine of interest in recent years, seems to be the most promising one studied to date. In contrast to leptin and resistin, adiponectin seems to be beneficial for health and it is a protective factor and decreased in obesity. However, many other factors derived from adipose tissue have also been discovered, such as interleukin-6, tumor necrosis factor alpha, monocyte chemoattractant protein 1, apelin, visfatin and probably others awaiting discovery in the near future. In this paper, we discussed the role of adipocytokines in the pathogenesis of atherosc...Continue Reading

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Citations

Oct 18, 2011·Odontology·Zuhal Yetkin AyNilgün Kapucuoğlu
Oct 15, 2011·Journal of the Royal Society, Interface·Sali LvXia Li
Nov 26, 2010·International Journal of Cardiology·Kwang Kon KohEak Kyun Shin
Jul 30, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amirhossein SahebkarClaudio Ferri
Aug 12, 2016·British Journal of Clinical Pharmacology·Amirhossein SahebkarClaudio Pedone
Aug 19, 2011·American Journal of Physiology. Endocrinology and Metabolism·Annabelle Reaux-Le GoazigoCatherine Llorens-Cortes
Jul 1, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xin SuBin Wang

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