A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Alexandre A SteinerAndrej A Romanovsky

Abstract

Obese (f/f) Koletsky rats lack the leptin receptor (LR), whereas their lean (F/?) counterparts bear a fully functional LR. By using f/f and F/? rats, we studied whether the LR is involved in lipopolysaccharide (LPS)-induced fever and hypothermia. The body temperature responses to LPS (10 or 100 microg/kg iv) were measured in Koletsky rats exposed to a thermoneutral (28 degrees C) or cool (22 degrees C) environment. Rats of both genotypes responded to LPS with fever at 28 degrees C and with dose-dependent hypothermia at 22 degrees C. The fever responses of the f/f and F/? rats were identical. The hypothermic response of the f/f rats was markedly prolonged compared with that of the F/? rats. The prolonged hypothermic response to LPS in the f/f rats was accompanied by enhanced NF-kappaB signaling in the hypothalamus and an exaggerated rise in the plasma concentration of tumor necrosis factor (TNF)-alpha. The f/f rats did not respond to LPS with an increase in the plasma concentration of corticosterone or adrenocorticotropic hormone, whereas their F/? counterparts did. The hypothermic response to TNF-alpha (80 microg/kg iv) was markedly prolonged in the f/f rats. These data show that the LR is essential for the recovery from LPS hy...Continue Reading

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Citations

Sep 25, 2009·Journal of Molecular Neuroscience : MN·Szilvia SoosErika Petervari
Apr 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catherine M KrallAlexandre A Steiner
May 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wataru InoueGiamal N Luheshi
Feb 14, 2012·Disease Models & Mechanisms·Catherine B LawrenceElysse M Knight
Aug 29, 2006·PLoS Biology·Alexandre A SteinerAndrej A Romanovsky
Dec 3, 2014·Hormones and Behavior·Elizabeth D Carlton, Gregory E Demas
Mar 27, 2009·Physiology & Behavior·Alexandre A SteinerElaine Liu
Feb 6, 2007·Progress in Lipid Research·Alexandre A Steiner, Andrej A Romanovsky
Jul 6, 2006·The European Journal of Neuroscience·Maria C AlmeidaAndrej A Romanovsky
Jul 18, 2006·Physiology & Behavior·Lois M HardenHelen P Laburn
Aug 12, 2014·Brain, Behavior, and Immunity·Joanna PohlGiamal N Luheshi
Mar 21, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Anders Blomqvist, David Engblom
Mar 17, 2015·Cell Cycle·Eszter PakaiAndrej A Romanovsky
Dec 4, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrei I IvanovAndrej A Romanovsky
Sep 26, 2017·Temperature : Multidisciplinary Biomedical Journal·Angela M Ramos-Lobo, Jose Donato
Apr 30, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandre A SteinerAndrej A Romanovsky
Jul 22, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tracey J WeilandStephen Kent
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Oct 15, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Pedro Rafael Firmino DiasDenise Vaz Macedo
Mar 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna EskilssonAnders Blomqvist
Feb 19, 2016·Physiology·Christoph RummelLois M Harden
Aug 6, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alla Y RudayaAndrej A Romanovsky
Aug 5, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth A FlatowAlexandre A Steiner
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Oct 31, 2020·Temperature : Multidisciplinary Biomedical Journal·Evilin N KomegaeAlexandre A Steiner

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