Aug 20, 2010

A new functional role of HIV-1 integrase during uncoating of the viral core

Immunologic Research
Marisa S Briones, Samson A Chow

Abstract

An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating.

  • References114
  • Citations6

References

Mentioned in this Paper

TRIM5gamma, human
Exertion
Integration, Provirus
Cyclophilin A
Virus Replication
HIV Infections
Capsid
PPIA gene
Host-Pathogen Interactions
P31 integrase protein, Human immunodeficiency virus 1

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