A new generation of oral direct anticoagulants

Arteriosclerosis, Thrombosis, and Vascular Biology
Gerald A Soff

Abstract

After more than 50 years of thrombosis treatment and prophylaxis being based on heparin and vitamin K antagonists, a new generation of oral, direct anticoagulants is now available. The past 5 years have brought a strikingly large number of trials that evaluated these new oral anticoagulants in a range of clinical trials, particularly nonvalvular atrial fibrillation, thrombosis prophylaxis after major joint replacement surgery, treatment of venous thromboembolic events, and, most recently, acute coronary syndrome. These studies have been notably similar in design between the drugs for specific indication. This review focuses on the 3 drugs that either have recently been approved by the US Food and Drug Administration (dabigatran and rivaroxaban) or have the most mature phase III clinical data (apixaban).

References

Jun 11, 2008·Journal of Thrombosis and Haemostasis : JTH·UNKNOWN Botticelli Investigators, Writing CommitteA Segers
Jun 27, 2008·The New England Journal of Medicine·Bengt I ErikssonUNKNOWN RECORD1 Study Group
Jun 27, 2008·The New England Journal of Medicine·Michael R LassenUNKNOWN RECORD3 Investigators
Aug 7, 2009·The New England Journal of Medicine·Michael Rud LassenRonald J Portman
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Dec 8, 2009·The New England Journal of Medicine·Sam SchulmanUNKNOWN RE-COVER Study Group
Nov 5, 2010·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN Randomized Evaluation of Long-Term Anticoagulation Therapy Investigators
Dec 7, 2010·The New England Journal of Medicine·Rupert BauersachsSebastian Schellong
Dec 24, 2010·The New England Journal of Medicine·Michael Rud LassenUNKNOWN ADVANCE-3 Investigators
Jan 14, 2011·Annual Review of Medicine·Bengt I ErikssonJohn W Eikelboom
Mar 2, 2011·Journal of Thrombosis and Thrombolysis·Alexander Thomas CohenVictor Tapson
Apr 15, 2011·The New England Journal of Medicine·B Nhi BeasleyRobert Temple
Jul 26, 2011·The New England Journal of Medicine·John H AlexanderUNKNOWN APPRAISE-2 Investigators
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators

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Citations

Feb 27, 2013·Journal of Thrombosis and Thrombolysis·Gerald A Soff
Jul 4, 2012·The Journal of Clinical Investigation·Nigel Mackman
Feb 4, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Martha L González Bárcenas, Ángeles Pérez Aisa
Oct 16, 2012·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Sun Zhi-JianJin Jin
Nov 11, 2015·Angiology·E SallaK N Syrigos
Feb 22, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Nigel Mackman
Feb 11, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Piao-Ping Hu, Kun-He Zhang
Jan 11, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Thomas EllerIngvild Birschmann
Jan 4, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Borros Arneth
May 28, 2017·The American Journal of Cardiology·Eva S LaubeSimon Mantha

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