A New Growth Model for Aortic Valve Calcification

Journal of Biomechanical Engineering
Rotem HaleviRami Haj-Ali

Abstract

Calcific aortic valve disease (CAVD) is a progressive disease in which minerals accumulate in the tissue of the aortic valve cusps, stiffening them and preventing valve opening and closing. The process of valve calcification was found to be similar to that of bone formation including cell differentiation to osteoblast-like cells. Studies have shown the contribution of high strains to calcification initiation and growth process acceleration. In this paper, a new strain-based calcification growth model is proposed. The model aims to explain the unique shape of the calcification and other disease characteristics. The calcification process was divided into two stages: Calcification initiation and calcification growth. The initiation locations were based on previously published findings and a reverse calcification technique (RCT), which uses computed tomography (CT) scans of patients to reveal the calcification initiation point. The calcification growth process was simulated by a finite element model of one aortic valve cusp loaded with cyclic loading. Similar to Wolff's law, describing bone response to stress, our model uses strains to drive calcification formation. The simulation grows calcification from its initiation point to it...Continue Reading

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Citations

Mar 22, 2021·Journal of Molecular and Cellular Cardiology·Boudewijn P T KruithofNina Ajmone Marsan
Apr 21, 2021·The International Journal of Cardiovascular Imaging·Kerstin PiaydaVerena Veulemans

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