A new heart failure model in rat by an end-to-side femoral vessel anastomosis

Cardiovascular Research
C OzekH J Buncke

Abstract

The aim of this study was to develop a new shunting procedure for producing heart failure in the rat incorporating microvascular techniques and avoiding an abdominal operation. We performed an end-to-side anastomosis between the femoral vein and the femoral artery just proximal to their trifurcation into the saphenous, epigastric, and distal femoral vessels. Of the 15 rats which underwent this procedure, six died within 48 h. The nine surviving animals were sacrificed and examined six weeks following surgery. All nine had developed cardiac hypertrophy and cardiac failure. This model provides a relatively simple and reproducible means of creating high output heart failure and cardiac hypertrophy in the rat without necessitating abdominal surgery.

Citations

Mar 27, 2012·Heart Failure Reviews·A C GomesA F Leite-Moreira
Jan 8, 2010·The Journal of Surgical Research·Aaron M AbarbanellDaniel R Meldrum
Sep 11, 2018·Journal of Vascular Research·Souleiman GhanemNorbert Nemeth

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