A new heterobinuclear FeIIICuII complex with a single terminal FeIII-O(phenolate) bond. Relevance to purple acid phosphatases and nucleases

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Mauricio LanznasterGerhard Schenk

Abstract

A novel heterobinuclear mixed valence complex [Fe(III)Cu(II)(BPBPMP)(OAc)(2)]ClO(4), 1, with the unsymmetrical N(5)O(2) donor ligand 2-bis[{(2-pyridylmethyl)aminomethyl}-6-{(2-hydroxybenzyl)(2-pyridylmethyl)}aminomethyl]-4-methylphenol (H(2)BPBPMP) has been synthesized and characterized. A combination of data from mass spectrometry, potentiometric titrations, X-ray absorption and electron paramagnetic resonance spectroscopy, as well as kinetics measurements indicates that in ethanol/water solutions an [Fe(III)-(mu)OH-Cu(II)OH(2)](+) species is generated which is the likely catalyst for 2,4-bis(dinitrophenyl)phosphate and DNA hydrolysis. Insofar as the data are consistent with the presence of an Fe(III)-bound hydroxide acting as a nucleophile during catalysis, 1 presents a suitable mimic for the hydrolytic enzyme purple acid phosphatase. Notably, 1 is significantly more reactive than its isostructural homologues with different metal composition (Fe(III)M(II), where M(II) is Zn(II), Mn(II), Ni(II), or Fe(II)). Of particular interest is the observation that cleavage of double-stranded plasmid DNA occurs even at very low concentrations of 1 (2.5 microM), under physiological conditions (optimum pH of 7.0), with a rate enhancement of...Continue Reading

References

May 30, 1978·Biochemical and Biophysical Research Communications·H D CampbellB Zerner
Jun 21, 1996·Journal of Molecular Biology·T KlabundeB Krebs
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J HalleenH K Väänänen
Aug 1, 1996·Italian Journal of Neurological Sciences·S al-Hussain, R al-Jomard
May 1, 1997·Medical Education·J Van den EndeE Van den Enden
Oct 6, 1997·Archives of Biochemistry and Biophysics·K MarshallS Hamilton
May 18, 1999·Journal of Molecular Biology·D KostrewaA P van Loon
Jun 22, 1999·Journal of Inorganic Biochemistry·J L BeckJ de Jersey
Jul 2, 1999·Journal of Molecular Biology·J UppenbergG Andersson
Jul 30, 1999·Structure·L W GuddatJ L Martin
Oct 8, 1999·Archives of Biochemistry and Biophysics·G SchenkJ de Jersey
Feb 10, 2000·Acta Crystallographica. Section D, Biological Crystallography·G SchenkL W Guddat
May 25, 2001·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·A Sreedhara, J A Cowan
Aug 22, 2001·Journal of Synchrotron Radiation·B Ravel
Aug 22, 2001·Journal of Synchrotron Radiation·M Newville
Dec 12, 2001·Current Opinion in Chemical Biology·J A Cowan
Nov 7, 1996·Chemical Reviews·Dean E. Wilcox
Mar 30, 2004·Archives of Biochemistry and Biophysics·Mohsen ValizadehSusan Hamilton
Dec 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gerhard SchenkLuke W Guddat

❮ Previous
Next ❯

Citations

Aug 19, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Sarah J SmithLawrence R Gahan
Oct 17, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Gerhard SchenkAdemir Neves
Jan 12, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Sarah J SmithMark J Riley
Feb 24, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Zhiming ZhangJunqiu Liu
Aug 28, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Anob KantachaLawrence R Gahan
Nov 3, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Luisa L MendesAdolfo Horn
Aug 16, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Graciela Aparecida Dos Santos SilvaRosely A Peralta
Dec 17, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Rebecca R BuchholzLawrence R Gahan
Aug 5, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Martin JarenmarkEbbe Nordlander
Jan 12, 2012·Chemistry : a European Journal·Peter CombaMarta Zajaczkowski-Fischer
Jul 4, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Claudia PereiraRosely A Peralta
Nov 21, 2012·The Analyst·Eduardo ZappIolanda C Vieira
Dec 16, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Lena J DaumannLawrence R Gahan
Feb 12, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Bernardo de SouzaAdemir Neves
Mar 23, 2021·Journal of Inorganic Biochemistry·Tiago P CamargoAdemir Neves
Aug 10, 2006·Chemical Reviews·Natasa MitićGerhard Schenk
Jun 8, 2010·Inorganic Chemistry·Maryene A CamargoMarcos N Eberlin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.