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A new HLA map of Europe: Regional genetic variation and its implication for peopling history, disease-association studies and tissue transplantation

Human Heredity

Jan 1, 2013

A Sanchez-MazasJ M Nunes

Abstract

HLA genes are highly polymorphic in human populations as a result of diversifying selection related to their immune function. However, HLA geographic variation worldwide suggests that demographic factors also shaped their evolution. We here analyzed in detail HLA genetic variation in Eu...read more

Mentioned in this Paper

Log-Linear Models
Genetics, Population
Candidate Gene Identification
HLA Antigens
Human Leukocyte Antigen (HLA) A Antigen Typing (Procedure)
Human Geography
RBM45 gene
Locus
Immune System Processes
Transplantation Aspects
Paper Details
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A new HLA map of Europe: Regional genetic variation and its implication for peopling history, disease-association studies and tissue transplantation

Human Heredity

Jan 1, 2013

A Sanchez-MazasJ M Nunes

PMID: 24861861

DOI: 10.1159/000360855

Abstract

HLA genes are highly polymorphic in human populations as a result of diversifying selection related to their immune function. However, HLA geographic variation worldwide suggests that demographic factors also shaped their evolution. We here analyzed in detail HLA genetic variation in Eu...read more

Mentioned in this Paper

Log-Linear Models
Genetics, Population
Candidate Gene Identification
HLA Antigens
Human Leukocyte Antigen (HLA) A Antigen Typing (Procedure)
Human Geography
RBM45 gene
Locus
Immune System Processes
Transplantation Aspects

Similar Papers Found In These Feeds

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Related Papers

Bulletin de l'Académie nationale de médecine

The first peopling of Europe: the extraordinary history of Neanderthal Man

Bulletin de l'Académie nationale de médecineDecember 1, 1992
Y Coppens
Cellular and Molecular Life Sciences : CMLS

Ancestry of modern Europeans: contributions of ancient DNA

Cellular and Molecular Life Sciences : CMLSOctober 12, 2012
Marie LacanBertrand Ludes
Paper Details
References
  • References
  • Citations16
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations16
12
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