A new hormone replacement therapy containing a progestogen with anti-mineralocorticoid activity

The Journal of the British Menopause Society
John C Stevenson

Abstract

Drospirenone is a new progestogen in hormone replacement therapy, with anti-mineralocorticoid activity. This anti-mineralocorticoid activity counteracts water and sodium retention, helping to reduce the likelihood of fluid retention that some women experience with hormone replacement therapy. In a post hoc analysis of women with mild hypertension, estradiol (1 mg) plus drospirenone (2 mg) was found to lower blood pressure in mildly hypertensive women. The introduction of estradiol plus drospirenone may offer the opportunity to re-evaluate the contribution of the progestogen component of hormone replacement therapy.

References

Feb 27, 2004·Cardiovascular Research·Allan D Struthers, Thomas M MacDonald
Mar 10, 2004·Climacteric : the Journal of the International Menopause Society·A Strothmann, H P G Schneider
Nov 10, 2005·Menopause : the Journal of the North American Menopause Society·David F ArcherRichard L Kempson

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Citations

Mar 17, 2007·Climacteric : the Journal of the International Menopause Society·D F Archer

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