A new hypothesis for foregut and heart tube formation based on differential growth and actomyosin contraction

Development
Hadi S HosseiniLarry A Taber

Abstract

For decades, it was commonly thought that the bilateral heart fields in the early embryo fold directly towards the midline, where they meet and fuse to create the primitive heart tube. Recent studies have challenged this view, however, suggesting that the heart fields fold diagonally. As early foregut and heart tube morphogenesis are intimately related, this finding also raises questions concerning the traditional view of foregut formation. Here, we combine experiments on chick embryos with computational modeling to explore a new hypothesis for the physical mechanisms of heart tube and foregut formation. According to our hypothesis, differential anisotropic growth between mesoderm and endoderm drives diagonal folding. Then, active contraction along the anterior intestinal portal generates tension to elongate the foregut and heart tube. We test this hypothesis using biochemical perturbations of cell proliferation and contractility, as well as computational modeling based on nonlinear elasticity theory including growth and contraction. The present results generally support the view that differential growth and actomyosin contraction drive formation of the foregut and heart tube in the early chick embryo.

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Citations

Jan 6, 2018·Circulation Research·Claudio CortesRobert G Kelly
Mar 12, 2020·Journal of Cardiovascular Development and Disease·Rusty Lansford, Sandra Rugonyi
Nov 27, 2019·Cold Spring Harbor Perspectives in Biology·Johannes G Wittig, Andrea Münsterberg
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Nov 5, 2019·International Journal for Numerical Methods in Biomedical Engineering·Mohammadali SharzeheeHai-Chao Han
Nov 12, 2020·Cell Stem Cell·Giuliana RossiMatthias P Lutolf

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