A new immune signature for survival prediction and immune checkpoint molecules in lung adenocarcinoma

Journal of Translational Medicine
Dina GuoJiaona Zhu

Abstract

Lung adenocarcinoma (LUAD) is the most frequent subtype of lung cancer. The prognostic signature could be reliable to stratify LUAD patients according to risk, which helps the management of the systematic treatments. In this study, a systematic and reliable immune signature was performed to estimate the prognostic stratification in LUAD. The profiles of immune-related genes for patients with LUAD were used as one TCGA training set: n = 494, other validation set 1: n = 226 and validation set 2: n = 398. Univariate Cox survival analysis was used to identify the candidate immune-related genes from each cohort. Then, the immune signature was developed and validated in the training and validation sets. In this study, functional analysis showed that immune-related genes involved in immune regulation and MAPK signaling pathway. A prognostic signature based on 10 immune-related genes was established in the training set and patients were divided into high-risk and low-risk groups. Our 10 immune-related gene signature was significantly related to worse survival, especially during early-stage tumors. Further stratification analyses revealed that this 10 immune-related gene signature was still an effective tool for predicting prognosis in ...Continue Reading

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Citations

Nov 15, 2020·International Journal of Molecular Sciences·Zhaodong LiFan Li
Jul 3, 2021·Nutrients·Michał SzczyrekJanusz Milanowski

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Software Mentioned

clusterProfiler
R Foundation for Statistical Computing
R
TIMER
FURIN
Genomic Data Commons

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