A new indole-alkaloid and a new phenolic-glycoside with cytotoxic activity from Strychnos fendleri

Natural Product Research
Alírica I SuárezStephen Tillett

Abstract

A new indole alkaloid strychnosinol (1) and a new phenolic-glycoside (2) were isolated from the bark and leaves of Strychnos fendleri Sprague & Sandwith, together with six known compounds reported for the first time in this species. The structures of these compounds were determined on the basis of spectroscopic data; mainly those obtained by using (1)H and (13)C NMR (1D and 2D) and mass spectrometry. Strychnosinol (1) and the phenolic glycoside (2) together with compounds 3-8 were evaluated for cytotoxicity against a panel of five tumour cell lines; IC50 values between 0.090 and 0.227 μM for the human tumour cell lines were observed for compound 2.

References

Feb 1, 1990·Journal of Ethnopharmacology·J Quetin-LeclercqN G Bisset
Aug 1, 1995·Phytochemistry·M M CorsaroM Parrilli
Dec 17, 2002·Phytochemistry·Zhao Feng PengLian Sai Chia
Jun 18, 2003·Phytochemistry·Eiko FujimatuJunichi Kitajima
Apr 28, 2007·Journal of Natural Products·Sheng LinJiangong Shi

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Citations

Aug 23, 2016·Natural Product Research·Jirapast SichaemSanti Tip-Pyang
Oct 13, 2017·Natural Product Research·Wei LiSheng Yin

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Methods Mentioned

BETA
NMR

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