A New Insight into Coating's Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant

Materials
Željka PetrovićMarin Petković

Abstract

Organophosphorus compounds, like bisphosphonates, drugs for treatment and prevention of bone diseases, have been successfully applied in recent years as bioactive and osseoinductive coatings on dental implants. An integrated experimental-theoretical approach was utilized in this study to clarify the mechanism of bisphosphonate-based coating formation on dental implant surfaces. Experimental validation of the alendronate coating formation on the titanium dental implant surface was carried out by X-ray photoelectron spectroscopy and contact angle measurements. Detailed theoretical simulations of all probable molecular implant surface/alendronate interactions were performed employing quantum chemical calculations at the density functional theory level. The calculated Gibbs free energies of (TiO2)10-alendronate interaction indicate a more spontaneous exergonic process when alendronate molecules interact directly with the titanium surface via two strong bonds, Ti-N and Ti-O, through simultaneous participation common to both phosphonate and amine branches. Additionally, the stability of the alendronate-modified implant during 7 day-immersion in a simulated saliva solution has been investigated by using electrochemical impedance spect...Continue Reading

References

Jan 1, 1969·Scandinavian Journal of Plastic and Reconstructive Surgery·P I BrånemarkA Ohlsson
Jan 1, 1983·Biomaterials·P I BrånemarkB Rockler
Jan 1, 1997·Journal of Biomedical Materials Research·Z L SunC T Hanks
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·H YuanK De Groot
Sep 6, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Nina AddenHenning Menzel
Jun 16, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Doris M SporiStefan Zürcher
Aug 30, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Rosalynn Quiñones, Ellen S Gawalt
Jan 12, 2008·Accounts of Chemical Research·Yan Zhao, Donald G Truhlar
Jun 3, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Gopinath ManiC Mauli Agrawal
Sep 6, 2011·Biochemical and Biophysical Research Communications·Ho-Jin MoonIl Keun Kwon
Dec 29, 2011·Journal of Materials Science. Materials in Medicine·F AgholmeP Aspenberg
Mar 27, 2012·Journal of Biomedical Materials Research. Part a·Jing HeZhongwei Gu
Feb 9, 2013·Biomaterials·Stuart B GoodmanFan Yang
Feb 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elisabeth V GigerJean-Christophe Leroux
Apr 9, 2014·Acta Biomaterialia·Rolando A GittensBarbara D Boyan
May 29, 2014·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Laura GaviriaJoo L Ong
Jan 13, 2015·Journal of Materials Science. Materials in Medicine·Johan KarlssonMartin Andersson
Mar 31, 2015·Beilstein Journal of Nanotechnology·Ognen Pop-GeorgievskiFrantišek Rypáček
Aug 2, 2016·BioMed Research International·Ralf SmeetsTobias Ebker
Sep 2, 2016·Journal of International Society of Preventive & Community Dentistry·Rajni AggarwalSharanpriya Sathnoorkar
Apr 4, 2017·International Journal of Oral and Maxillofacial Surgery·S V KellesarianF Javed
May 29, 2018·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Magdalena Łukaszewska-KuskaBarbara Dorocka-Bobkowska
Oct 14, 2018·International Journal of Oral and Maxillofacial Surgery·V MendesV Moraschini

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